Jorge Henna Neto1, Hélio Elkis. 1. Institute of Psychiatry, Hospital das Clínicas, Medical School, Universidade de São Paulo, São Paulo, SP, Brazil. henna@usp.br
Abstract
OBJECTIVE: Approximately 30% of treatment-resistant schizophrenic patients do not fully respond to Clozapine and such patients are termed Clozapine non-responders or super-refractory schizophrenics. The aim of this study was to characterize patients with super-refractory schizophrenia according to demographic and psychopathological variables, as compared with patients with refractory schizophrenia or non-refractory subjects. METHOD: One hundred two outpatients meeting DSM-IV criteria for schizophrenia were followed-up for 6 months. Subjects were classified into 3 groups: non-refractory (n=25), refractory (n=43) and super-refractory (n=34). Psychopathology was assessed by the Positive and Negative Syndrome Scale, the Schedule for Deficit Syndrome, the Calgary Depression Scale and the Quality of Life Scale. Patients were rated at 2-month intervals. RESULTS: Higher levels of severity at the disease onset as well as higher severity of positive symptoms were found to be predictive of super-refractoriness. CONCLUSIONS: The super-refractory schizophrenia patients have psychopathological predictive factors that need studies comparing brain images, genetical features and other clinical comparisons.
OBJECTIVE: Approximately 30% of treatment-resistant schizophrenicpatients do not fully respond to Clozapine and such patients are termed Clozapine non-responders or super-refractory schizophrenics. The aim of this study was to characterize patients with super-refractory schizophrenia according to demographic and psychopathological variables, as compared with patients with refractory schizophrenia or non-refractory subjects. METHOD: One hundred two outpatients meeting DSM-IV criteria for schizophrenia were followed-up for 6 months. Subjects were classified into 3 groups: non-refractory (n=25), refractory (n=43) and super-refractory (n=34). Psychopathology was assessed by the Positive and Negative Syndrome Scale, the Schedule for Deficit Syndrome, the Calgary Depression Scale and the Quality of Life Scale. Patients were rated at 2-month intervals. RESULTS: Higher levels of severity at the disease onset as well as higher severity of positive symptoms were found to be predictive of super-refractoriness. CONCLUSIONS: The super-refractory schizophreniapatients have psychopathological predictive factors that need studies comparing brain images, genetical features and other clinical comparisons.
Authors: J P Maia-de-Oliveira; J P Pinto; V Alexandre; J P Machado-de-Sousa; S L Morais; C Chaves; A C Sakamoto; A W Zuardi; J A S Crippa; J E Hallak Journal: Case Rep Med Date: 2010-03-11