| Literature DB >> 17890096 |
Richa Chaturvedi1, Jamie Heimburg, Jun Yan, Stephen Koury, Munawwar Sajjad, Hani H Abdel-Nabi, Kate Rittenhouse-Olson.
Abstract
Clinical immunolocalization has been attempted by others with an anti-Thomsen-Friedenreich antigen (TF-Ag) mAb that bound both alpha- and beta-linked TF-Ag. In this report, 124 I-labeled mAb JAA-F11 specific for alpha-linked TF-Ag showed higher tumor specificity in in vivo micro-positron emission tomography (micro-PET) of the mouse mammary adenocarcinoma line, 4T1, showing no preferential uptake by the kidney. Labeled product remained localized in the tumor for at least 20 days. Glycan array analysis showed structural specificity of the antibody.Entities:
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Year: 2007 PMID: 17890096 PMCID: PMC3192430 DOI: 10.1016/j.apradiso.2007.07.029
Source DB: PubMed Journal: Appl Radiat Isot ISSN: 0969-8043 Impact factor: 1.513