Literature DB >> 17890096

Tumor immunolocalization using 124 I-iodine-labeled JAA-F11 antibody to Thomsen-Friedenreich alpha-linked antigen.

Richa Chaturvedi1, Jamie Heimburg, Jun Yan, Stephen Koury, Munawwar Sajjad, Hani H Abdel-Nabi, Kate Rittenhouse-Olson.   

Abstract

Clinical immunolocalization has been attempted by others with an anti-Thomsen-Friedenreich antigen (TF-Ag) mAb that bound both alpha- and beta-linked TF-Ag. In this report, 124 I-labeled mAb JAA-F11 specific for alpha-linked TF-Ag showed higher tumor specificity in in vivo micro-positron emission tomography (micro-PET) of the mouse mammary adenocarcinoma line, 4T1, showing no preferential uptake by the kidney. Labeled product remained localized in the tumor for at least 20 days. Glycan array analysis showed structural specificity of the antibody.

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Year:  2007        PMID: 17890096      PMCID: PMC3192430          DOI: 10.1016/j.apradiso.2007.07.029

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN: 0969-8043            Impact factor:   1.513


  20 in total

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