OBJECTIVE: To determine whether further histologic assessment can be omitted after office sampling produced a nondiagnostic specimen. METHODS: Data were retrieved from a prospective cohort study of 913 women presenting with postmenopausal bleeding. This study was limited to women with an endometrial thickness either 5 mm or greater or that could not be measured, and in whom an endometrial biopsy performed in the office yielded nondiagnostic results. RESULTS: Endometrial thickness was nonreassuring or unknown in 516 women, of whom 403 (78.1%) underwent office endometrial sampling. In 66 women the amount of tissue obtained was not sufficient for pathologic characterization. Further investigation revealed an endometrial malignancy in 3 of these 66 women and atypical hyperplasia in 1. CONCLUSION: In women with postmenopausal bleeding and a nonreassuring transvaginal ultrasound evaluation, a nondiagnostic office endometrial sample does not rule out endometrial cancer and further endometrial sampling is advisable.
OBJECTIVE: To determine whether further histologic assessment can be omitted after office sampling produced a nondiagnostic specimen. METHODS: Data were retrieved from a prospective cohort study of 913 women presenting with postmenopausal bleeding. This study was limited to women with an endometrial thickness either 5 mm or greater or that could not be measured, and in whom an endometrial biopsy performed in the office yielded nondiagnostic results. RESULTS: Endometrial thickness was nonreassuring or unknown in 516 women, of whom 403 (78.1%) underwent office endometrial sampling. In 66 women the amount of tissue obtained was not sufficient for pathologic characterization. Further investigation revealed an endometrial malignancy in 3 of these 66 women and atypical hyperplasia in 1. CONCLUSION: In women with postmenopausal bleeding and a nonreassuring transvaginal ultrasound evaluation, a nondiagnostic office endometrial sample does not rule out endometrial cancer and further endometrial sampling is advisable.
Authors: M C Breijer; N van Hanegem; N C M Visser; R H M Verheijen; B W J Mol; J M A Pijnenborg; B C Opmeer; A Timmermans Journal: ScientificWorldJournal Date: 2015-02-16
Authors: Nicole C M Visser; Ellen M Sparidaens; Jan-Willem van den Brink; Maria C Breijer; Erik A Boss; Sebastiaan Veersema; Albert G Siebers; Johan Bulten; Johanna M A Pijnenborg; Ruud L M Bekkers Journal: Acta Obstet Gynecol Scand Date: 2016-10-14 Impact factor: 3.636
Authors: M C Breijer; N C M Visser; N van Hanegem; A A van der Wurff; B C Opmeer; H C van Doorn; B W J Mol; J M A Pijnenborg; A Timmermans Journal: Int J Surg Oncol Date: 2016-03-13