Literature DB >> 17889641

DISC1 puts the brakes on neurogenesis.

Alex Dranovsky1, Rene Hen.   

Abstract

The gene DISC1 (Disrupted-in-Schizophrenia 1) is a leading candidate gene for schizophrenia. In this issue, Duan et al. (2007) present evidence implicating DISC1 in the maturation and integration of newly generated neurons in the adult mouse hippocampus. Surprisingly, DISC1 appears to have opposite effects on neurogenesis during development and in adulthood.

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Year:  2007        PMID: 17889641     DOI: 10.1016/j.cell.2007.09.004

Source DB:  PubMed          Journal:  Cell        ISSN: 0092-8674            Impact factor:   41.582


  6 in total

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Authors:  Maarten Otter; Constance T R M Schrander-Stumpel; Leopold M G Curfs
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Review 3.  Quantitative neuroproteomics: classical and novel tools for studying neural differentiation and function.

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4.  Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice.

Authors:  Mirna Kvajo; Heather McKellar; Liam J Drew; Aude-Marie Lepagnol-Bestel; Lan Xiao; Rebecca J Levy; Richard Blazeski; P Alexander Arguello; Clay O Lacefield; Carol A Mason; Michel Simonneau; James M O'Donnell; Amy B MacDermott; Maria Karayiorgou; Joseph A Gogos
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-02       Impact factor: 11.205

Review 5.  Hippocampal granule cell pathology in epilepsy - a possible structural basis for comorbidities of epilepsy?

Authors:  Michael S Hester; Steve C Danzer
Journal:  Epilepsy Behav       Date:  2014-01-24       Impact factor: 2.937

Review 6.  Hippocampal neurogenesis as a target for the treatment of mental illness: a critical evaluation.

Authors:  Nathan A DeCarolis; Amelia J Eisch
Journal:  Neuropharmacology       Date:  2010-01-06       Impact factor: 5.250

  6 in total

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