Literature DB >> 17889551

Gonadotropin-regulated testicular helicase (GRTH/DDX25): an essential regulator of spermatogenesis.

Maria L Dufau1, Chon-Hwa Tsai-Morris.   

Abstract

Male germ-cell maturation is orchestrated by a cascade of temporally regulated factors. Gonadotropin-regulated testicular helicase (GRTH/DDX25), a target of gonadotropin and androgen action, is a post-transcriptional regulator of key spermatogenesis genes. Male mice lacking GRTH are sterile, with spermatogenic arrest owing to the failure of round spermatids to elongate. GRTH is a component of messenger ribonucleoprotein particles, which transport target mRNAs to the cytoplasm for storage in chromatoid bodies of spermatids; these messages are released for translation during spermatogenesis. GRTH is also found in polyribosomes, where it regulates the translation of mRNAs encoding spermatogenesis factors. The association of GRTH mutations with male infertility underlines the importance of GRTH as a central, post-transcriptional regulator of spermatogenesis.

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Year:  2007        PMID： 17889551     DOI： 10.1016/j.tem.2007.09.001

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  23 in total

Review 1.  Transcription and post-transcriptional regulation of spermatogenesis.

Authors:  Anilkumar Bettegowda; Miles F Wilkinson
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2010-05-27       Impact factor: 6.237

2.  Relevance of gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) in the structural integrity of the chromatoid body during spermatogenesis.

Authors:  Hisashi Sato; Chon-Hwa Tsai-Morris; Maria L Dufau
Journal:  Biochim Biophys Acta       Date:  2010-02-20

Review 3.  A census of human RNA-binding proteins.

Authors:  Stefanie Gerstberger; Markus Hafner; Thomas Tuschl
Journal:  Nat Rev Genet       Date:  2014-11-04       Impact factor: 53.242

4.  GRTH: a key to understanding androgen-mediated germ cell signaling.

Authors:  Carole R Mendelson
Journal:  Endocrinology       Date:  2013-06       Impact factor: 4.736

5.  Germ Cell Nuclear Factor (GCNF/RTR) Regulates Transcription of Gonadotropin-Regulated Testicular RNA Helicase (GRTH/DDX25) in Testicular Germ Cells--The Androgen Connection.

Authors:  Raghuveer Kavarthapu; Maria L Dufau
Journal:  Mol Endocrinol       Date:  2015-10-20

6.  Expression of DDX25 in nuage components of mammalian spermatogenic cells: immunofluorescence and immunoelectron microscopic study.

Authors:  Yuko Onohara; Sadaki Yokota
Journal:  Histochem Cell Biol       Date:  2011-10-29       Impact factor: 4.304

7.  A 5'-flanking region of gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) gene directs its cell-specific androgen-regulated gene expression in testicular germ cells.

Authors:  Raghuveer Kavarthapu; Chon-Hwa Tsai-Morris; Masato Fukushima; James Pickel; Maria L Dufau
Journal:  Endocrinology       Date:  2013-04-01       Impact factor: 4.736

8.  Comparative structural analysis of human DEAD-box RNA helicases.

Authors:  Patrick Schütz; Tobias Karlberg; Susanne van den Berg; Ruairi Collins; Lari Lehtiö; Martin Högbom; Lovisa Holmberg-Schiavone; Wolfram Tempel; Hee-Won Park; Martin Hammarström; Martin Moche; Ann-Gerd Thorsell; Herwig Schüler
Journal:  PLoS One       Date:  2010-09-30       Impact factor: 3.240

Review 9.  Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25): a multifunctional protein essential for spermatogenesis.

Authors:  Chon-Hwa Tsai-Morris; Yi Sheng; Ravi K Gutti; Pei-Zhong Tang; Maria L Dufau
Journal:  J Androl       Date:  2009-10-29

10.  The DEXD/H-box RNA helicase DDX19 is regulated by an {alpha}-helical switch.

Authors:  Ruairi Collins; Tobias Karlberg; Lari Lehtiö; Patrick Schütz; Susanne van den Berg; Lars-Göran Dahlgren; Martin Hammarström; Johan Weigelt; Herwig Schüler
Journal:  J Biol Chem       Date:  2009-02-25       Impact factor: 5.157
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