Literature DB >> 17889364

Apoptosis induction by Maackia amurensis agglutinin in childhood acute lymphoblastic leukemic cells.

Sarika Kapoor1, Ram Marwaha, Siddhartha Majumdar, Sujata Ghosh.   

Abstract

Malignant transformation is known to be associated with changes in cell surface carbohydrate-architecture, which can be detected by lectins. In the present study, Maackia amurensis agglutinin (MAA), specific for NeuNAcalpha(2-->3)Gal/GalNAc showed strong binding with lymphoblasts of children having acute lymphoblastic leukemia (ALL) as compared to cells from children with non-hematological disorders ("Controls"). MAA recognized a 66 kDa sialoglycoprotein present in membrane fraction of ALL cells. Moreover, MAA induced apoptosis in ALL cells was found to be reduced significantly in presence of GM2/IgG(MAA). Thus, MAA has a potential to be used as diagnostic and therapeutic agent in case of childhood-ALL.

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Year:  2007        PMID： 17889364     DOI： 10.1016/j.leukres.2007.08.007

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  5 in total

1.  Maackia amurensis agglutinin induces apoptosis in cultured drug resistant human non-small cell lung cancer cells.

Authors:  Rakhee Chhetra Lalli; Kiranjeet Kaur; Anuradha Chakraborti; Radhika Srinivasan; Sujata Ghosh
Journal:  Glycoconj J       Date:  2019-11-22       Impact factor: 2.916

2.  Purification and molecular cloning of a new galactose-specific lectin from Bauhinia variegata seeds.

Authors:  Luciano S Pinto; Celso S Nagano; Taianá M Oliveira; Tales R Moura; Alexandre H Sampaio; Henri Debray; Vicente P Pinto; Odir A Dellagostin; Benildo S Cavada
Journal:  J Biosci       Date:  2008-09       Impact factor: 1.826

3.  Glycosylation-Dependent Induction of Programmed Cell Death in Murine Adenocarcinoma Cells.

Authors:  Aleksei Parshenkov; Thierry Hennet
Journal:  Front Immunol       Date:  2022-02-10       Impact factor: 7.561

4.  Maackia amurensis seed lectin (MASL) ameliorates articular cartilage destruction and increases movement velocity of mice with TNFα induced rheumatoid arthritis.

Authors:  Kelly L Hamilton; Amanda A Greenspan; Alan J Shienbaum; Bradford D Fischer; Andrea Bottaro; Gary S Goldberg
Journal:  Biochem Biophys Rep       Date:  2022-09-09

5.  Plant lectin can target receptors containing sialic acid, exemplified by podoplanin, to inhibit transformed cell growth and migration.

Authors:  Jhon Alberto Ochoa-Alvarez; Harini Krishnan; Yongquan Shen; Nimish K Acharya; Min Han; Dean E McNulty; Hitoki Hasegawa; Toshinori Hyodo; Takeshi Senga; Jian-Guo Geng; Mary Kosciuk; Seung S Shin; James S Goydos; Dmitry Temiakov; Robert G Nagele; Gary S Goldberg
Journal:  PLoS One       Date:  2012-07-23       Impact factor: 3.240
  5 in total

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