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Literature DB >> 17889091

Biotransformation of adrenosterone by filamentous fungus, Cunninghamella elegans.

Muhammad Iqbal Choudhary¹, Naik T Khan, Syed G Musharraf, Shazia Anjum.

Abstract

Microbial transformation of adrenosterone (1) by suspended-cell cultures of the filamentous fungus Cunninghamella elegans resulted in the production of five metabolites 2-6, which were identified as 9alpha-hydroxyadrenosterone (2), 11-ketotestosterone (3), 6beta-hydroxyadrenosterone (4), 9alpha-hydroxy-11-ketotestosterone (5), and 6beta-hydroxy-11-ketotestosterone (6). Structures of new metabolites 2, 5, and 6 were established by single-crystal X-ray diffraction analysis.

Entities: Chemical Species

Mesh：

Substances：
Androstenes
adrenosterone

Year: 2007 PMID： 17889091 DOI： 10.1016/j.steroids.2007.08.002

Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668

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Cited

13 in total

1. Metabolic Profile of Synthetic Cannabinoids 5F-PB-22, PB-22, XLR-11 and UR-144 by Cunninghamella elegans.

Authors: Shimpei Watanabe; Unnikrishnan Kuzhiumparambil; My Ann Nguyen; Jane Cameron; Shanlin Fu
Journal: AAPS J Date: 2017-04-28 Impact factor: 4.009

2. Microbial transformation of mestanolone by Macrophomina phaseolina and Cunninghamella blakesleeana and anticancer activities of the transformed products.

Authors: Rabia Farooq; Nusrat Hussain; Sammer Yousuf; Malik Shoaib Ahmad; M Iqbal Choudhary
Journal: RSC Adv Date: 2018-06-14 Impact factor: 4.036

3. Synthesis of some potent immunomodulatory and anti-inflammatory metabolites by fungal transformation of anabolic steroid oxymetholone.

Authors: Naik Tameen Khan; Marium Bibi; Sammer Yousuf; Izhar Husain Qureshi; Null Atta-Ur-Rahman; Abdullah Mohammad Al-Majid; Muhammad Ahmed Mesaik; Ahmed Shukralla Khalid; Samina A Sattar; Null Atia-Tul-Wahab; M Iqbal Choudhary
Journal: Chem Cent J Date: 2012-12-10 Impact factor: 4.215

4. Biotransformation of a potent anabolic steroid, mibolerone, with Cunninghamella blakesleeana, C. echinulata, and Macrophomina phaseolina, and biological activity evaluation of its metabolites.

Authors: Mahwish Siddiqui; Malik Shoaib Ahmad; Atia-Tul- Wahab; Sammer Yousuf; Narjis Fatima; Nimra Naveed Shaikh; Atta-Ur- Rahman; M Iqbal Choudhary
Journal: PLoS One Date: 2017-02-24 Impact factor: 3.240

5. Bio-Catalytic Structural Transformation of Anti-cancer Steroid, Drostanolone Enanthate with Cephalosporium aphidicola and Fusarium lini, and Cytotoxic Potential Evaluation of Its Metabolites against Certain Cancer Cell Lines.

Authors: M Iqbal Choudhary; Mahwish Siddiqui; Sammer Yousuf; Narjis Fatima; Malik S Ahmad; Hani Choudhry
Journal: Front Pharmacol Date: 2017-12-20 Impact factor: 5.810

6. Microbial transformation of anti-cancer steroid exemestane and cytotoxicity of its metabolites against cancer cell lines.

Authors: Elias Baydoun; Marium Bibi; Muhammad Asif Iqbal; Atia-Tul Wahab; Dina Farran; Colon Smith; Samina A Sattar; Atta-Ur Rahman; M Iqbal Choudhary
Journal: Chem Cent J Date: 2013-03-27 Impact factor: 4.215

Biotransformation of adrenosterone by filamentous fungus, Cunninghamella elegans.

1. Metabolic Profile of Synthetic Cannabinoids 5F-PB-22, PB-22, XLR-11 and UR-144 by Cunninghamella elegans.

2. Microbial transformation of mestanolone by Macrophomina phaseolina and Cunninghamella blakesleeana and anticancer activities of the transformed products.

3. Synthesis of some potent immunomodulatory and anti-inflammatory metabolites by fungal transformation of anabolic steroid oxymetholone.

4. Biotransformation of a potent anabolic steroid, mibolerone, with Cunninghamella blakesleeana, C. echinulata, and Macrophomina phaseolina, and biological activity evaluation of its metabolites.

5. Bio-Catalytic Structural Transformation of Anti-cancer Steroid, Drostanolone Enanthate with Cephalosporium aphidicola and Fusarium lini, and Cytotoxic Potential Evaluation of Its Metabolites against Certain Cancer Cell Lines.

6. Microbial transformation of anti-cancer steroid exemestane and cytotoxicity of its metabolites against cancer cell lines.

7. Data on individual metabolites of synthetic cannabinoids JWH-018, JWH-073 and AM2201 by Cunninghamella elegans.

Review 8. Microbial Biotransformation to Obtain New Antifungals.

Review 9. Overview on the Biochemical Potential of Filamentous Fungi to Degrade Pharmaceutical Compounds.

10. Biotransformation of steroids by entomopathogenic strains of Isaria farinosa.