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Literature DB >> 17888661

Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase.

Yongge Qiu¹, Jinbo Gao, Fei Guo, Yuqin Qiao, Ding Li.

Abstract

Mevalonate 5-diphosphate decarboxylase plays an important role in regulating cholesterol biosynthesis, which was studied through incubation with various synthetic substrate analogs and characterization of mutated enzymes. The results are potentially useful for further developing inhibitors that block the mevalonate pathway which is a drug target for treating cardiovascular disease and cancer.

Entities: Chemical Disease

Mesh：

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Year: 2007 PMID： 17888661 DOI： 10.1016/j.bmcl.2007.09.033

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

7 in total

1. Structural analysis of mevalonate-3-kinase provides insight into the mechanisms of isoprenoid pathway decarboxylases.

Authors: Jeffrey M Vinokur; Tyler P Korman; Michael R Sawaya; Michael Collazo; Duillio Cascio; James U Bowie
Journal: Protein Sci Date: 2014-12-26 Impact factor: 6.725

Review 2. Enzymes of the mevalonate pathway of isoprenoid biosynthesis.

Authors: Henry M Miziorko
Journal: Arch Biochem Biophys Date: 2010-10-07 Impact factor: 4.013

3. Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure.

Authors: Natalia E Voynova; Zhuji Fu; Kevin P Battaile; Timothy J Herdendorf; Jung-Ja P Kim; Henry M Miziorko
Journal: Arch Biochem Biophys Date: 2008-09-18 Impact factor: 4.013

4. Mevalonate 5-diphosphate mediates ATP binding to the mevalonate diphosphate decarboxylase from the bacterial pathogen Enterococcus faecalis.

Authors: Chun-Liang Chen; James C Mermoud; Lake N Paul; Calvin Nicklaus Steussy; Cynthia V Stauffacher
Journal: J Biol Chem Date: 2017-10-12 Impact factor: 5.157

Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase.

1. Structural analysis of mevalonate-3-kinase provides insight into the mechanisms of isoprenoid pathway decarboxylases.

Review 2. Enzymes of the mevalonate pathway of isoprenoid biosynthesis.

3. Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure.

4. Mevalonate 5-diphosphate mediates ATP binding to the mevalonate diphosphate decarboxylase from the bacterial pathogen Enterococcus faecalis.

5. An Adaptation To Life In Acid Through A Novel Mevalonate Pathway.

6. Applying asymptotic methods to synthetic biology: Modelling the reaction kinetics of the mevalonate pathway.

7. Visualizing the enzyme mechanism of mevalonate diphosphate decarboxylase.