AIM: To compare the prevalence of transient periventricular echodensities (TPE), periventricular leukomalacia (PVL) and haemorrhagic brain lesions (HBL) in singleton intrauterine growth-restricted (IUGR) infants and in those appropriate for gestational age (AGA). METHODS: Thirty-five IUGR and 35 AGA singleton infants born between 24- and 34-week gestational age were studied. The presence of TPE, PVL and HBL was assessed with ultrasound (US) at day 3 (US-I), 2 weeks (US-II) after delivery and at term-equivalent age (US-III). RESULTS: IUGR neonates had an increased prevalence of TPE at US-I (18/35 vs. 8/35, p= 0.02) and an increased prevalence of PVL at US-II (8/32 vs. 1/31, p = 0.03) and US-III (8/29 vs. 1/29, p = 0.02). No significant differences in the prevalence of HBL were found between the two groups. CONCLUSIONS: IUGR is associated with an increased prevalence of white matter damage on US brain scans in preterm neonates.
AIM: To compare the prevalence of transient periventricular echodensities (TPE), periventricular leukomalacia (PVL) and haemorrhagic brain lesions (HBL) in singleton intrauterine growth-restricted (IUGR) infants and in those appropriate for gestational age (AGA). METHODS: Thirty-five IUGR and 35 AGA singleton infants born between 24- and 34-week gestational age were studied. The presence of TPE, PVL and HBL was assessed with ultrasound (US) at day 3 (US-I), 2 weeks (US-II) after delivery and at term-equivalent age (US-III). RESULTS: IUGR neonates had an increased prevalence of TPE at US-I (18/35 vs. 8/35, p= 0.02) and an increased prevalence of PVL at US-II (8/32 vs. 1/31, p = 0.03) and US-III (8/29 vs. 1/29, p = 0.02). No significant differences in the prevalence of HBL were found between the two groups. CONCLUSIONS: IUGR is associated with an increased prevalence of white matter damage on US brain scans in preterm neonates.
Authors: Atul Malhotra; Michael Ditchfield; Michael C Fahey; Margie Castillo-Melendez; Beth J Allison; Graeme R Polglase; Euan M Wallace; Ryan Hodges; Graham Jenkin; Suzanne L Miller Journal: Pediatr Res Date: 2017-05-17 Impact factor: 3.756
Authors: Leigh R Campbell; Yi Pang; Norma B Ojeda; Baoying Zheng; Philip G Rhodes; Barbara T Alexander Journal: Pediatr Res Date: 2012-02-15 Impact factor: 3.756
Authors: Amy E Sutherland; Tamara Yawno; Margie Castillo-Melendez; Beth J Allison; Atul Malhotra; Graeme R Polglase; Leo J Cooper; Graham Jenkin; Suzanne L Miller Journal: Front Cell Neurosci Date: 2020-04-30 Impact factor: 5.505