| Literature DB >> 17887664 |
Natasa Terzić1, Dejan Opsenica, Dragana Milić, Bernard Tinant, Kirsten S Smith, Wilbur K Milhous, Bogdan A Solaja.
Abstract
The synthesis of deoxycholic acid (DCA)- and cholic acid (CA)-derived mixed tetraoxanes revealed that N-(2-dimethylamino)ethyl derivatives are potent antimalarials in vitro and in vivo. The tetraoxanes presented in this paper are dual inhibitors: besides curing mice in vivo without observed toxic effects, they kill cancer cell lines at very low concentrations. For example, DCA and CA derivatives 16 and 25 cured 3/5 (160 mg/kg/day) and 2/5 (40 mg/kg/day, MTD >960 mg/kg), respectively, and they were extremely active against melanoma LOX IMVI cancer, LC50 = 22 nM and 69 nM, respectively.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17887664 DOI： 10.1021/jm070684m
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446