Literature DB >> 17886231

Antileishmanial, antiplasmodial and cytotoxic activities of 12,16-dideoxy aegyptinone B from Zhumeria majdae Rech.f. & Wendelbo.

Mahmood Reza Moein1, Rahul S Pawar, Shabana I Khan, Babu L Tekwani, Ikhlas A Khan.   

Abstract

The ethanol extract of Zhumeria majdae showed potent antileishmanial and antiplasmodial activity in vitro. Bioactivity guided fractionation of the extract led to the isolation of 12,16-dideoxy aegyptinone B. This compound exhibited potent in vitro antileishmanial activity with an IC(50) of 0.75 microg/mL and a strong antiplasmodial activity with IC(50) values of 1.3 and 1.4 microg/mL against chloroquine sensitive and resistant strains, respectively. This compound was further found to have mild cytotoxicity towards cancer cell lines.

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Year:  2008        PMID： 17886231     DOI： 10.1002/ptr.2305

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  9 in total

1.  Antiplasmodial activity of botanical extracts against Plasmodium falciparum.

Authors:  Asokan Bagavan; Abdul Abdul Rahuman; Chinnaperumal Kamaraj; Naveen Kumar Kaushik; Dinesh Mohanakrishnan; Dinkar Sahal
Journal:  Parasitol Res       Date:  2010-11-16       Impact factor: 2.289

2.  Anticonvulsant activity and toxicity of essential oil and methanolic extract of Zhumeria majdae Rech, a unique Iranian plant in mice.

Authors:  Ali Mandegary; Fariba Sharififar; Maryam Abdar; Milad Arab-Nozari
Journal:  Neurochem Res       Date:  2012-08-14       Impact factor: 3.996

3.  Antileishmanial Activities of Greek Juniper (Juniperus excelsa M.Bieb.) Against Leishmania major Promastigotes.

Authors:  Mahmoodreza Moein; Gholamreza Hatam; Razieh Taghavi-Moghadam; Mohammad M Zarshenas
Journal:  J Evid Based Complementary Altern Med       Date:  2016-01-08

4.  Antiprotozoal activity of diterpenoids isolated from Zhumeria majdae- absolute configuration by circular dichroism.

Authors:  Reza Zadali; Samad Nejad Ebrahimi; Zahra Tofighi; Ali Es-Haghi; Matthias Hamburger; Marcel Kaiser; Massimiliano D' Ambola; Nunziatina De Tommasi; Abbas Hadjiakhoondi
Journal:  Daru       Date:  2020-05-11       Impact factor: 3.117

Review 5.  Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts.

Authors:  Eric Deharo; Hagai Ginsburg
Journal:  Malar J       Date:  2011-03-15       Impact factor: 2.979

6.  Anticonvulsant Activity of Essential Oil From Leaves of Zhumeria majdae (Rech.) in Mice: The Role of GABAA Neurotransmission and the Nitric Oxide Pathway.

Authors:  Helia Aghamiri; Hamed Shafaroodi; Jinous Asgarpanah
Journal:  Clin Transl Sci       Date:  2020-04-08       Impact factor: 4.689

7.  Comparative volatile composition, antioxidant and cytotoxic evaluation of the essential oil of Zhumeria majdae from south of Iran.

Authors:  Mansoor Saeidi; Javad Asili; Seyed Ahmad Emami; Nasrin Moshtaghi; Saeid Malekzadeh-Shafaroudi
Journal:  Iran J Basic Med Sci       Date:  2019-01       Impact factor: 2.699

Review 8.  Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy.

Authors:  Diogo Vilar da Fonsêca; Carlos da Silva Maia Bezerra Filho; Tamires Cardoso Lima; Reinaldo Nóbrega de Almeida; Damião Pergentino de Sousa
Journal:  Biomolecules       Date:  2019-12-06

Review 9.  Plant-derived antimalarial agents: new leads and efficient phytomedicines. Part II. Non-alkaloidal natural products.

Authors:  Ronan Batista; Ademir de Jesus Silva; Alaíde Braga de Oliveira
Journal:  Molecules       Date:  2009-08-13       Impact factor: 4.411
  9 in total

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