BACKGROUND: Resistin is a protein produced by adipocytes and circulating macrophages that has been found to be associated with inflammatory states. OBJECTIVE: To determine the levels of resistin in relation to asthma disease state and severity, we investigated a cohort of adult patients with asthma. METHODS: A cohort of moderate to severe persistent asthma patients and control patients were recruited and underwent fasting labs to evaluate levels of serum glucose, C-reactive protein (CRP), and resistin. RESULTS: No significant differences were found between the control and asthma group with respect to serum CRP at 0.78 +/- 0.60 mg/dL and 0.48 +/- 0.60 mg/dL, (p < 0.36) or glucose at 92.2 +/- 11.9 mg/dL and 89.5 +/- 7.2 mg/dL, (p < 0.084), respectively (mean +/- SD). However, plasma resistin levels were found to be significantly elevated in asthma patients, 186 ng/mL (95%CI 169-202) compared with control patients 121 ng/mL (95%CI 90.4-151), (p < 0.005). CONCLUSIONS: Patients with asthma were found to have higher levels of resistin, and resistin levels were increased with disease severity in the asthma cohort.
BACKGROUND:Resistin is a protein produced by adipocytes and circulating macrophages that has been found to be associated with inflammatory states. OBJECTIVE: To determine the levels of resistin in relation to asthma disease state and severity, we investigated a cohort of adult patients with asthma. METHODS: A cohort of moderate to severe persistent asthmapatients and control patients were recruited and underwent fasting labs to evaluate levels of serum glucose, C-reactive protein (CRP), and resistin. RESULTS: No significant differences were found between the control and asthma group with respect to serum CRP at 0.78 +/- 0.60 mg/dL and 0.48 +/- 0.60 mg/dL, (p < 0.36) or glucose at 92.2 +/- 11.9 mg/dL and 89.5 +/- 7.2 mg/dL, (p < 0.084), respectively (mean +/- SD). However, plasma resistin levels were found to be significantly elevated in asthmapatients, 186 ng/mL (95%CI 169-202) compared with control patients 121 ng/mL (95%CI 90.4-151), (p < 0.005). CONCLUSIONS:Patients with asthma were found to have higher levels of resistin, and resistin levels were increased with disease severity in the asthma cohort.
Authors: N Sismanopoulos; D-A Delivanis; D Mavrommati; E Hatziagelaki; P Conti; T C Theoharides Journal: Allergy Date: 2012-10-16 Impact factor: 13.146