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Literature DB >> 17885783

Successful use of recombinant factor VIIa (NovoSeven) during cardiac surgery in a pediatric patient with congenital factor XI deficiency.

Zekai Avci¹, Baris Malbora, Mahmut Gokdemir, Suleyman Ozkan, Namik Ozbek.

Abstract

We report our experience with the use of recombinant activated factor VII (rFVIIa) during cardiac surgery in a 4.5-year-old boy with severe congenital FXI deficiency and a congenital heart disease. After weaning the patient from cardiopulmonary bypass, the first intravenous dose of rFVIIa (90 microg/kg) was administered. This same dosage was repeated eight more times, at 2- to 4-hour intervals postoperatively. There was no bleeding during and after surgery. rFVIIa treatment may be used successfully in children with severe FXI deficiency in major operations such as open heart surgery.

Entities: Disease Species

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Year: 2007 PMID： 17885783 DOI： 10.1007/s00246-007-9081-3

Source DB: PubMed Journal: Pediatr Cardiol ISSN： 0172-0643 Impact factor: 1.655

15 in total

Successful use of recombinant factor VIIa (NovoSeven) during cardiac surgery in a pediatric patient with congenital factor XI deficiency.

Review 1. Factor XI deficiency--from molecular genetics to clinical management.

2. Palliative open heart surgery in an infant with factor VII deficiency.

3. What dose of recombinant activated factor VII should be used in patients with factor XI deficiency?

Review 4. Safety, efficacy and lessons from continuous infusion with rFVIIa. rFVIIa-CI Group.

5. An illustrative case and a review on the dosing of recombinant factor VIIa in congenital factor XI deficiency.

Review 6. Treatment of factor XI inhibitor using recombinant activated factor VIIa.

7. A novel factor XI gene mutation associated with mild factor XI deficiency in a symptomatic patient.

8. Successful use of recombinant factor VIIa in a patient with inhibitor secondary to severe factor XI deficiency.

9. New observations on factor XI deficiency.

10. Cardiac surgery with extracorporeal circulation in severe factor VII deficiency.

1. Recombinant activated factor VII in controlling bleeding in non-hemophiliac patients.

2. A Case Report of Severe Factor XI Deficiency during Cardiac Surgery: Less Can Be More.