Literature DB >> 17885303

The intestinal mucosa as a reservoir of HIV-1 infection after successful HAART.

Liliana Belmonte1, Martin Olmos, Ana Fanin, Cecilia Parodi, Patricia Baré, Hugo Concetti, Héctor Pérez, Maria Marta E de Bracco, Pedro Cahn.   

Abstract

The presence of HIV-1 RNA in distal duodenal mucosa was evaluated in 44 HIV-1-positive patients. HIV-1 RNA was detected in gut tissue in antiretroviral-naive patients with high plasma viral loads, as well as in patients on HAART with plasma viral loads below the limit of detection and in patients on HAART with virological failure. The intestinal mucosa seems to serve as a reservoir poorly influenced by levels of plasma viral load or HAART.

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Year:  2007        PMID： 17885303     DOI： 10.1097/QAD.0b013e3282efb74b

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  37 in total

Review 1.  The multifaceted nature of HIV latency.

Authors:  Caroline Dufour; Pierre Gantner; Rémi Fromentin; Nicolas Chomont
Journal:  J Clin Invest       Date:  2020-07-01       Impact factor: 14.808

2.  The large intestine as a major reservoir for simian immunodeficiency virus in macaques with long-term, nonprogressing infection.

Authors:  Binhua Ling; Mahesh Mohan; Andrew A Lackner; Linda C Green; Preston A Marx; Lara A Doyle; Ronald S Veazey
Journal:  J Infect Dis       Date:  2010-11-04       Impact factor: 5.226

Review 3.  Total HIV-1 DNA, a Marker of Viral Reservoir Dynamics with Clinical Implications.

Authors:  Véronique Avettand-Fènoël; Laurent Hocqueloux; Jade Ghosn; Antoine Cheret; Pierre Frange; Adeline Melard; Jean-Paul Viard; Christine Rouzioux
Journal:  Clin Microbiol Rev       Date:  2016-10       Impact factor: 26.132

4.  The distribution of HIV DNA and RNA in cell subsets differs in gut and blood of HIV-positive patients on ART: implications for viral persistence.

Authors:  Steven A Yukl; Amandeep K Shergill; Terence Ho; Maudi Killian; Valerie Girling; Lorrie Epling; Peilin Li; Lisa K Wong; Pierre Crouch; Steven G Deeks; Diane V Havlir; Kenneth McQuaid; Elizabeth Sinclair; Joseph K Wong
Journal:  J Infect Dis       Date:  2013-07-12       Impact factor: 5.226

5.  A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells.

Authors:  Steven A Yukl; Elizabeth Sinclair; Ma Somsouk; Peter W Hunt; Lorrie Epling; Maudi Killian; Valerie Girling; Peilin Li; Diane V Havlir; Steven G Deeks; Joseph K Wong; Hiroyu Hatano
Journal:  AIDS       Date:  2014-01-28       Impact factor: 4.177

6.  Effect of combination antiretroviral therapy on Chinese rhesus macaques of simian immunodeficiency virus infection.

Authors:  Binhua Ling; Linda Rogers; Ann-Marie Johnson; Michael Piatak; Jeffrey Lifson; Ronald S Veazey
Journal:  AIDS Res Hum Retroviruses       Date:  2013-03-08       Impact factor: 2.205

7.  Antiretroviral therapy prior to acute viral replication preserves CD4 T cells in the periphery but not in rectal mucosa during acute simian immunodeficiency virus infection.

Authors:  Muhamuda Kader; Wail M Hassan; Matthew Eberly; Michael Piatak; Jeffrey D Lifson; Mario Roederer; Joseph J Mattapallil
Journal:  J Virol       Date:  2008-09-03       Impact factor: 5.103

8.  Anti-retroviral therapy fails to restore the severe Th-17: Tc-17 imbalance observed in peripheral blood during simian immunodeficiency virus infection.

Authors:  M Kader; S Bixler; M Piatak; J Lifson; J J Mattapallil
Journal:  J Med Primatol       Date:  2009-10       Impact factor: 0.667

9.  Increased mutations in Env and Pol suggest greater HIV-1 replication in sputum-derived viruses compared with blood-derived viruses.

Authors:  Thor A Wagner; Nicole H Tobin; Jennifer L McKernan; Min Xu; Ann J Melvin; Kathleen M Mohan; Gerald H Learn; James I Mullins; Lisa M Frenkel
Journal:  AIDS       Date:  2009-05-15       Impact factor: 4.177

10.  Synthetic consensus HIV-1 DNA induces potent cellular immune responses and synthesis of granzyme B, perforin in HIV infected individuals.

Authors:  Matthew P Morrow; Pablo Tebas; Jian Yan; Lorenzo Ramirez; Anna Slager; Kim Kraynyak; Malissa Diehl; Divya Shah; Amir Khan; Jessica Lee; Jean Boyer; J Joseph Kim; Niranjan Y Sardesai; David B Weiner; Mark L Bagarazzi
Journal:  Mol Ther       Date:  2014-12-22       Impact factor: 11.454
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