Literature DB >> 1788475

Experimental infection of goat fetuses in utero with a stable, rough mutant of Brucella abortus.

R M Roop1, G Jeffers, T Bagchi, J Walker, F M Enright, G G Schurig.   

Abstract

Fetuses of goats in their last trimester of pregnancy were experimentally infected with Brucella abortus strain RB51, a stable rough mutant deficient in the perosamine O-chain content of its lipopolysaccharide. RB51 maintained its rough phenotype in vivo and did not induce abortion. Infection with RB51 resulted in the production of significant levels of IgG type antibodies specific for B abortus cellular antigens distinct from the perosamine O-chain. These findings suggest that strain RB51 will be useful in the pregnant goat for studying the role of brucella antigens other than the lipopolysaccharide O-chain in the immune response to brucellosis.

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Year:  1991        PMID： 1788475     DOI： 10.1016/0034-5288(91)90001-5

Source DB:  PubMed          Journal:  Res Vet Sci        ISSN： 0034-5288            Impact factor:   2.534


  8 in total

1.  Determination of stability of Brucella abortus RB51 by use of genomic fingerprint, oxidative metabolism, and colonial morphology and differentiation of strain RB51 from B. abortus isolates from bison and elk.

Authors:  A E Jensen; D R Ewalt; N F Cheville; C O Thoen; J B Payeur
Journal:  J Clin Microbiol       Date:  1996-03       Impact factor: 5.948

2.  Immune responses and resistance to brucellosis in mice vaccinated orally with Brucella abortus RB51.

Authors:  M G Stevens; S C Olsen; M V Palmer; G W Pugh
Journal:  Infect Immun       Date:  1996-11       Impact factor: 3.441

3.  Antibody responses to Brucella abortus 2308 in cattle vaccinated with B. abortus RB51.

Authors:  M G Stevens; S C Olsen
Journal:  Infect Immun       Date:  1996-03       Impact factor: 3.441

Review 4.  Survival of the fittest: how Brucella strains adapt to their intracellular niche in the host.

Authors:  R Martin Roop; Jennifer M Gaines; Eric S Anderson; Clayton C Caswell; Daniel W Martin
Journal:  Med Microbiol Immunol       Date:  2009-09-22       Impact factor: 3.402

5.  Vaccination with Brucella abortus rough mutant RB51 protects BALB/c mice against virulent strains of Brucella abortus, Brucella melitensis, and Brucella ovis.

Authors:  M P Jiménez de Bagüés; P H Elzer; S M Jones; J M Blasco; F M Enright; G G Schurig; A J Winter
Journal:  Infect Immun       Date:  1994-11       Impact factor: 3.441

6.  Progress in Brucella vaccine development.

Authors:  Xinghong Yang; Jerod A Skyberg; Ling Cao; Beata Clapp; Theresa Thornburg; David W Pascual
Journal:  Front Biol (Beijing)       Date:  2013-02-01

7.  Identification of an immunoreactive Brucella abortus HtrA stress response protein homolog.

Authors:  R M Roop; T W Fletcher; N M Sriranganathan; S M Boyle; G G Schurig
Journal:  Infect Immun       Date:  1994-03       Impact factor: 3.441

Review 8.  Uncovering the Hidden Credentials of Brucella Virulence.

Authors:  R Martin Roop; Ian S Barton; Dariel Hopersberger; Daniel W Martin
Journal:  Microbiol Mol Biol Rev       Date:  2021-02-10       Impact factor: 11.056
  8 in total

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