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Literature DB >> 17884627

Combinatorial enzymatic synthesis of heparan sulfate.

Abstract

Escherichia coli K5 heparosan was enzymatically modified by Chen and colleagues to construct a library of heparan sulfate polysaccharides for evaluation, leading to the discovery that a 2-O-sulfoiduronic acid residue is not essential for antithrombin-mediated anticoagulant activity in larger oligosaccharide and polysaccharide structures.

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Year: 2007 PMID： 17884627 PMCID： PMC4142598 DOI： 10.1016/j.chembiol.2007.09.002

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

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References

9 in total

Review 1. Order out of chaos: assembly of ligand binding sites in heparan sulfate.

Authors: Jeffrey D Esko; Scott B Selleck
Journal: Annu Rev Biochem Date: 2001-11-09 Impact factor: 23.643

2. 2003 Claude S. Hudson Award address in carbohydrate chemistry. Heparin: structure and activity.

Authors: Robert J Linhardt
Journal: J Med Chem Date: 2003-06-19 Impact factor: 7.446

3. Generation of "neoheparin" from E. coli K5 capsular polysaccharide.

Authors: Ulf Lindahl; Jin-Ping Li; Marion Kusche-Gullberg; Markku Salmivirta; Sakari Alaranta; Timo Veromaa; Jef Emeis; Ian Roberts; Clare Taylor; Pasqua Oreste; Giorgio Zoppetti; Annamaria Naggi; Giangiacomo Torri; Benito Casu
Journal: J Med Chem Date: 2005-01-27 Impact factor: 7.446

4. Enzymatic redesigning of biologically active heparan sulfate.

Authors: Jinghua Chen; Fikri Y Avci; Eva M Muñoz; Lynda M McDowell; Miao Chen; Lars C Pedersen; Lijuan Zhang; Robert J Linhardt; Jian Liu
Journal: J Biol Chem Date: 2005-10-31 Impact factor: 5.157

5. Enzymatic synthesis of heparin related polysaccharides on sensor chips: rapid screening of heparin-protein interactions.

Authors: Eva Muñoz; Ding Xu; Fikri Avci; Melissa Kemp; Jian Liu; Robert J Linhardt
Journal: Biochem Biophys Res Commun Date: 2005-11-17 Impact factor: 3.575

Combinatorial enzymatic synthesis of heparan sulfate.

Review 1. Order out of chaos: assembly of ligand binding sites in heparan sulfate.

2. 2003 Claude S. Hudson Award address in carbohydrate chemistry. Heparin: structure and activity.

3. Generation of "neoheparin" from E. coli K5 capsular polysaccharide.

4. Enzymatic redesigning of biologically active heparan sulfate.

5. Enzymatic synthesis of heparin related polysaccharides on sensor chips: rapid screening of heparin-protein interactions.

Review 6. Chemical approaches to define the structure-activity relationship of heparin-like glycosaminoglycans.

7. Contribution of monosaccharide residues in heparin binding to antithrombin III.

8. Using an enzymatic combinatorial approach to identify anticoagulant heparan sulfate structures.

9. Enzymatic synthesis of antithrombin III-binding heparan sulfate pentasaccharide.