OBJECTIVE: The aim of this study was to determine the prevalence of celiac disease among the adult population of Madrid by measuring antibodies against tissue transglutaminase as serologic screening method. POPULATION AND METHODS: 2,215 subjects participated voluntarily in this study. All of them completed a clinical questionnaire. We determined the levels of total IgA and antibodies to tissue transglutaminase (tTG). An intestinal biopsy by endoscopy was proposed to all subjects who were tTG-positive. The histologic lesion was classified in accordance to Marsh. RESULTS: Three known CD cases were identified by the questionnaire. Eleven donors with tTG positivity were detected, all of them asymptomatic. Four subjects rejected the intestinal biopsy. Seven out of 11 positive subjects consented to undergo a duodenal biopsy -3 had villous atrophy and 4 had increased intraepithelial lymphocyte counts with normal villi. In our study the number of donors with biopsy-proven CD was 6, and the prevalence was 1/370. If we include the subcategories of gluten sensitive enteropathy (Marsh I), the prevalence would be 1/222. When we considered antibody positivity the prevalence of gluten sensitivity was 1 in 201, and it reached 1 in 158 when the three known CD cases were included. CONCLUSIONS: Data on CD prevalence in this study confirm that CD is a first-line healthcare problem that may warrant universal screening. We detected a high number of lymphocytic enteritis cases, and thus some sort of action is mandatory.
OBJECTIVE: The aim of this study was to determine the prevalence of celiac disease among the adult population of Madrid by measuring antibodies against tissue transglutaminase as serologic screening method. POPULATION AND METHODS: 2,215 subjects participated voluntarily in this study. All of them completed a clinical questionnaire. We determined the levels of total IgA and antibodies to tissue transglutaminase (tTG). An intestinal biopsy by endoscopy was proposed to all subjects who were tTG-positive. The histologic lesion was classified in accordance to Marsh. RESULTS: Three known CD cases were identified by the questionnaire. Eleven donors with tTG positivity were detected, all of them asymptomatic. Four subjects rejected the intestinal biopsy. Seven out of 11 positive subjects consented to undergo a duodenal biopsy -3 had villous atrophy and 4 had increased intraepithelial lymphocyte counts with normal villi. In our study the number of donors with biopsy-proven CD was 6, and the prevalence was 1/370. If we include the subcategories of gluten sensitive enteropathy (Marsh I), the prevalence would be 1/222. When we considered antibody positivity the prevalence of gluten sensitivity was 1 in 201, and it reached 1 in 158 when the three known CD cases were included. CONCLUSIONS: Data on CD prevalence in this study confirm that CD is a first-line healthcare problem that may warrant universal screening. We detected a high number of lymphocytic enteritis cases, and thus some sort of action is mandatory.
Authors: Julia María Cabo Del Riego; María Jesús Núñez Iglesias; Carmen García-Plata González; José Paz Carreira; Tamara Álvarez Fernández; Ana Dorado Díaz; Noa Villar Mallo; Manuel Penedo Pita; Silvia Novío Mallón; Lola Máiz Suárez; Manuel Freire-Garabal Núñez Journal: Int J Environ Res Public Health Date: 2022-04-20 Impact factor: 4.614
Authors: Ricardo Fueyo-Díaz; Rosa Magallón-Botaya; Barbara Masluk; Guillermo Palacios-Navarro; Angela Asensio-Martínez; Santiago Gascón-Santos; Bárbara Olivan-Blázquez; Juan José Sebastián-Domingo Journal: BMC Health Serv Res Date: 2019-08-16 Impact factor: 2.655
Authors: Francisco J Martinez-Orozco; Miguel Fernandez-Arquero; Jose L Vicario; Laura Lillo-Triguero; Elena Ameyugo; Rosa Peraita-Adrados Journal: J Clin Med Res Date: 2022-08-27
Authors: Francisco Javier Martinez-Orozco; Jose Luis Vicario; Clara De Andres; Miguel Fernandez-Arquero; Rosa Peraita-Adrados Journal: J Clin Med Res Date: 2016-05-29