Pretreatment with caerulein protects against memory impairment induced by protein kinase C inhibitors in the rat.

The effect of subcutaneously injected caerulein (CER) on memory impairment induced by protein kinase C (PKC) inhibitors, H-7 and melittin, was examined in rats. Intracerebroventricular injection of PKC inhibitors caused marked memory impairment in one-trial passive avoidance response and Morris water tank tasks. However, when rats were pretreated with CER at a subcutaneous dose of 1 microgram/kg 3 hours before the training trials, the reduced latency of the passive avoidance response was significantly increased, and in the Morris water pool tasks the memory deficit induced by PKC inhibitors completely disappeared. These results indicate that CER can offer protection against the effect of PKC inhibitors at least from the viewpoint of the memory processes.