INTRODUCTION: Depression is discussed as a possible risk factor for survival in cancer patients. We explored this relationship for patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT). PATIENTS AND METHODS: The depression subscale of the Hospital Anxiety and Depression Scale (HADS) served as a measure for depression. One hundred and thirty-eight patients (mean age 41 years; different diagnoses) participating in a psycho-oncology study filled in the HADS after admission for allogeneic HSCT. They were followed-up for at least two years; 72 patients died during follow-up. RESULTS: Depression scores were not correlated with medical and psychosocial objective factors with the exception of having under-aged children. Controlling for medical factors that showed up as predictors for survival in our sample (patient's age at HSCT, having had a transplant before, risk for treatment failure) the HADS depression score (range 0-21) emerged as an independent predictor (Cox regression): hazard ratio = 1.087, 95% CI = 1.018-1.161. CONCLUSION: Depression is probably not a simple indicator of a worse health status. Further research is needed to decide if depression must be considered as an independent risk factor for survival when diagnosed in the pre-transplant period.
INTRODUCTION:Depression is discussed as a possible risk factor for survival in cancerpatients. We explored this relationship for patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT). PATIENTS AND METHODS: The depression subscale of the Hospital Anxiety and Depression Scale (HADS) served as a measure for depression. One hundred and thirty-eight patients (mean age 41 years; different diagnoses) participating in a psycho-oncology study filled in the HADS after admission for allogeneic HSCT. They were followed-up for at least two years; 72 patients died during follow-up. RESULTS:Depression scores were not correlated with medical and psychosocial objective factors with the exception of having under-aged children. Controlling for medical factors that showed up as predictors for survival in our sample (patient's age at HSCT, having had a transplant before, risk for treatment failure) the HADS depression score (range 0-21) emerged as an independent predictor (Cox regression): hazard ratio = 1.087, 95% CI = 1.018-1.161. CONCLUSION:Depression is probably not a simple indicator of a worse health status. Further research is needed to decide if depression must be considered as an independent risk factor for survival when diagnosed in the pre-transplant period.
Authors: William A Wood; Jennifer Le-Rademacher; Karen L Syrjala; Heather Jim; Paul B Jacobsen; Jennifer M Knight; Muneer H Abidi; John R Wingard; Navneet S Majhail; Nancy L Geller; J Douglas Rizzo; Mingwei Fei; Juan Wu; Mary M Horowitz; Stephanie J Lee Journal: Cancer Date: 2015-10-06 Impact factor: 6.860
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Authors: Bonnie A McGregor; Karen L Syrjala; Emily D Dolan; Shelby L Langer; Mary Redman Journal: Brain Behav Immun Date: 2012-08-13 Impact factor: 7.217