Literature DB >> 17879298

Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: studies in rodents.

Igor P Pogribny1, Ivan Rusyn, Frederick A Beland.   

Abstract

Hepatocellular carcinoma, which is one of the most prevalent life-threatening human cancers, is showing an increased incidence worldwide. Recent evidence indicates that the development of hepatocellular carcinoma is associated with not only genetic alterations, but also with profound epigenetic changes. This review summarizes the current knowledge about epigenetic alterations during rodent hepatocarcinogenesis, considers the similarities and differences in epigenetic effects of genotoxic and non-genotoxic rodent liver carcinogens, and discusses the possible role of these effects in the causality of liver tumor development.

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Year:  2008        PMID： 17879298      PMCID： PMC2705440          DOI： 10.1002/em.20342

Source DB:  PubMed          Journal:  Environ Mol Mutagen        ISSN： 0893-6692            Impact factor:   3.216


  63 in total

1.  A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells.

Authors:  Slimane Ait-Si-Ali; Valentina Guasconi; Lauriane Fritsch; Hakima Yahi; Redha Sekhri; Irina Naguibneva; Philippe Robin; Florence Cabon; Anna Polesskaya; Annick Harel-Bellan
Journal:  EMBO J       Date:  2004-02-05       Impact factor: 11.598

Review 2.  The history of cancer epigenetics.

Authors:  Andrew P Feinberg; Benjamin Tycko
Journal:  Nat Rev Cancer       Date:  2004-02       Impact factor: 60.716

3.  Site-specific hypomethylation of c-myc protooncogene in liver nodules and inhibition of DNA methylation by N-nitrosomorpholine.

Authors:  P A Münzel; A Pfohl-Leszkowicz; E Röhrdanz; G Keith; G Dirheimer; K W Bock
Journal:  Biochem Pharmacol       Date:  1991-07-05       Impact factor: 5.858

4.  Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16(INK4A) exon 1 in hepatocellular carcinoma.

Authors:  T J Park; H S Kim; K H Byun; J J Jang; Y S Lee; I K Lim
Journal:  Mol Carcinog       Date:  2001-03       Impact factor: 4.784

Review 5.  Cytosine methylation and the ecology of intragenomic parasites.

Authors:  J A Yoder; C P Walsh; T H Bestor
Journal:  Trends Genet       Date:  1997-08       Impact factor: 11.639

6.  Methyl groups in carcinogenesis: effects on DNA methylation and gene expression.

Authors:  E Wainfan; L A Poirier
Journal:  Cancer Res       Date:  1992-04-01       Impact factor: 12.701

7.  Correlation between DNA methylation and pathological changes in human hepatocellular carcinoma.

Authors:  L Shen; J Fang; D Qiu; T Zhang; J Yang; S Chen; S Xiao
Journal:  Hepatogastroenterology       Date:  1998 Sep-Oct

8.  De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats.

Authors:  Igor P Pogribny; S Jill James
Journal:  Cancer Lett       Date:  2002-12-10       Impact factor: 8.679

9.  High incidence of hepatocellular carcinomas induced by a choline deficient L-amino acid defined diet in rats.

Authors:  D Nakae; H Yoshiji; Y Mizumoto; K Horiguchi; K Shiraiwa; K Tamura; A Denda; Y Konishi
Journal:  Cancer Res       Date:  1992-09-15       Impact factor: 12.701

10.  Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha.

Authors:  Igor P Pogribny; Volodymyr P Tryndyak; Courtney G Woods; Sarah E Witt; Ivan Rusyn
Journal:  Mutat Res       Date:  2007-05-18       Impact factor: 2.433
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  8 in total

1.  Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene.

Authors:  Igor Koturbash; Anne Scherhag; Jessica Sorrentino; Kenneth Sexton; Wanda Bodnar; James A Swenberg; Frederick A Beland; Fernando Pardo-Manuel Devillena; Ivan Rusyn; Igor P Pogribny
Journal:  Toxicol Sci       Date:  2011-05-20       Impact factor: 4.849

2.  Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver.

Authors:  Igor P Pogribny; Volodymyr P Tryndyak; Anna Boureiko; Stepan Melnyk; Tetyana V Bagnyukova; Beverly Montgomery; Ivan Rusyn
Journal:  Mutat Res       Date:  2008-07-01       Impact factor: 2.433

Review 3.  Advances in chemical carcinogenesis: a historical review and prospective.

Authors:  Lawrence A Loeb; Curtis C Harris
Journal:  Cancer Res       Date:  2008-09-01       Impact factor: 12.701

Review 4.  Environmental toxicants, epigenetics, and cancer.

Authors:  Igor P Pogribny; Ivan Rusyn
Journal:  Adv Exp Med Biol       Date:  2013       Impact factor: 2.622

5.  Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene.

Authors:  Igor Koturbash; Anne Scherhag; Jessica Sorrentino; Kenneth Sexton; Wanda Bodnar; Volodymyr Tryndyak; John R Latendresse; James A Swenberg; Frederick A Beland; Igor P Pogribny; Ivan Rusyn
Journal:  Environ Health Perspect       Date:  2010-12-13       Impact factor: 9.031

Review 6.  Non‑infective occupational risk factors for hepatocellular carcinoma: A review (Review).

Authors:  Caterina Ledda; Carla Loreto; Christian Zammit; Andrea Marconi; Lucrezia Fago; Serena Matera; Valentina Costanzo; Giovanni Fuccio Sanzà; Stefano Palmucci; Margherita Ferrante; Chiara Costa; Concettina Fenga; Antonio Biondi; Cristoforo Pomara; Venerando Rapisarda
Journal:  Mol Med Rep       Date:  2016-12-14       Impact factor: 2.952

7.  Gene silencing of Nox4 by CpG island methylation during hepatocarcinogenesis in rats.

Authors:  Guadalupe S López-Álvarez; Tomasz K Wojdacz; Claudia M García-Cuellar; Hugo C Monroy-Ramírez; Miguel A Rodríguez-Segura; Ruth A Pacheco-Rivera; Carlos A Valencia-Antúnez; Nancy Cervantes-Anaya; Ernesto Soto-Reyes; Verónica R Vásquez-Garzón; Yesennia Sánchez-Pérez; Saúl Villa-Treviño
Journal:  Biol Open       Date:  2017-01-15       Impact factor: 2.422

8.  Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome.

Authors:  John P Thomson; Harri Lempiäinen; Jamie A Hackett; Colm E Nestor; Arne Müller; Federico Bolognani; Edward J Oakeley; Dirk Schübeler; Rémi Terranova; Diana Reinhardt; Jonathan G Moggs; Richard R Meehan
Journal:  Genome Biol       Date:  2012-10-03       Impact factor: 13.583
  8 in total

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