OBJECTIVES: To determine accuracy and intertest agreement of preoperative fine-needle aspiration cytology (FNAC) and intraoperative frozen-section analysis (FS) findings in thyroid surgery, and to assess the influence of intraoperative FS findings on decision making and the utility of FS in thyroid surgery. DESIGN: Retrospective analysis. The results of preoperative FNAC, intraoperative FS, and final histopathological analyses were taken from the histopathology reports. We calculated intertest agreement using the kappa statistic. PATIENTS: Two-hundred fifteen patients who underwent primary thyroid surgery. All patients were treated by the same surgeon (S.J.W.). RESULTS: T he sensitivity and specificity of FNAC were 57.4% and 91.7%, respectively. The sensitivity and specificity of FS were 32.4% and 96.5%, respectively. The intertest agreement was poor (kappa = 0.17). In case of malignant FNAC findings, the FS result did not influence treatment decisions; in case of a malignant FS result on the background of a benign, indeterminate, or nondiagnostic FNAC finding, the FS result influenced treatment decisions in 88% of cases. CONCLUSIONS: Intraoperative FS did not give additional information in cases where a malignant neoplasm was predicted by the FNAC finding. In this setting, it led to conflicting results and did not contribute to correct decision making.
OBJECTIVES: To determine accuracy and intertest agreement of preoperative fine-needle aspiration cytology (FNAC) and intraoperative frozen-section analysis (FS) findings in thyroid surgery, and to assess the influence of intraoperative FS findings on decision making and the utility of FS in thyroid surgery. DESIGN: Retrospective analysis. The results of preoperative FNAC, intraoperative FS, and final histopathological analyses were taken from the histopathology reports. We calculated intertest agreement using the kappa statistic. PATIENTS: Two-hundred fifteen patients who underwent primary thyroid surgery. All patients were treated by the same surgeon (S.J.W.). RESULTS: T he sensitivity and specificity of FNAC were 57.4% and 91.7%, respectively. The sensitivity and specificity of FS were 32.4% and 96.5%, respectively. The intertest agreement was poor (kappa = 0.17). In case of malignant FNAC findings, the FS result did not influence treatment decisions; in case of a malignant FS result on the background of a benign, indeterminate, or nondiagnostic FNAC finding, the FS result influenced treatment decisions in 88% of cases. CONCLUSIONS:Intraoperative FS did not give additional information in cases where a malignant neoplasm was predicted by the FNAC finding. In this setting, it led to conflicting results and did not contribute to correct decision making.
Authors: Hee Jung Moon; Jin Young Kwak; Eun-Kyung Kim; Min Jung Kim; Cheong Soo Park; Woung Youn Chung; Eun Ju Son Journal: World J Surg Date: 2009-05 Impact factor: 3.352
Authors: Badr Ibrahim; Véronique-Isabelle Forest; Michael Hier; Alex M Mlynarek; Derin Caglar; Richard J Payne Journal: J Otolaryngol Head Neck Surg Date: 2015-06-16
Authors: Mario Siller; Lea Maria Stangassinger; Christina Kreutzer; Peter Boor; Roman D Bulow; Theo J F Kraus; Saskia von Stillfried; Soraya Wolfl; Sebastien Couillard-Despres; Gertie Janneke Oostingh; Anton Hittmair; Michael Gadermayr Journal: J Pathol Inform Date: 2022-01-05