BACKGROUND: E-selectin is a key adhesion molecule which plays a fundamental role in endothelial progenitor cell-dependent reparative mechanisms in experimental ischaemia and it serves to anchor leucocytes to the endothelium in inflammatory processes. Inflammation is one of the strongest risk factors for death and cardiovascular (CV) events in end-stage renal disease (ESRD). OBJECTIVE: The objective of the current study was to evaluate whether E-selectin is a useful biomarker of clinical outcome in ESRD patients. We tested the prediction power of circulating E-selectin for mortality and CV events in a cohort of 265 ESRD patients. RESULTS: During the follow-up, 59 patients died and 58 had CV events. All-cause mortality was inversely related to serum E-selectin, the risk of death being the lowest in patients in the third E-selectin tertile (HR: 1, reference group), intermediate in those in the second tertile (HR: 1.30) and the highest in patients in the first tertile (HR: 2.02, P = 0.01). Similarly, the risk of fatal and nonfatal CV events followed an inverse pattern being lowest in the third tertile (reference group) and highest in the first tertile (HR: 1.73, P = 0.03). The prediction power of E-selectin for death and CV events was confirmed in a Cox regression analysis where E-selectin emerged as an inverse predictor of these outcomes, particularly so in patients with severe inflammation. CONCLUSIONS: These data are in keeping with the hypothesis that in systemic inflammation altered E-selectin shedding may play a role in arterial damage and implicates this adhesion molecule in atherosclerotic complications in a high-risk condition like ESRD.
BACKGROUND:E-selectin is a key adhesion molecule which plays a fundamental role in endothelial progenitor cell-dependent reparative mechanisms in experimental ischaemia and it serves to anchor leucocytes to the endothelium in inflammatory processes. Inflammation is one of the strongest risk factors for death and cardiovascular (CV) events in end-stage renal disease (ESRD). OBJECTIVE: The objective of the current study was to evaluate whether E-selectin is a useful biomarker of clinical outcome in ESRDpatients. We tested the prediction power of circulating E-selectin for mortality and CV events in a cohort of 265 ESRDpatients. RESULTS: During the follow-up, 59 patients died and 58 had CV events. All-cause mortality was inversely related to serum E-selectin, the risk of death being the lowest in patients in the third E-selectin tertile (HR: 1, reference group), intermediate in those in the second tertile (HR: 1.30) and the highest in patients in the first tertile (HR: 2.02, P = 0.01). Similarly, the risk of fatal and nonfatal CV events followed an inverse pattern being lowest in the third tertile (reference group) and highest in the first tertile (HR: 1.73, P = 0.03). The prediction power of E-selectin for death and CV events was confirmed in a Cox regression analysis where E-selectin emerged as an inverse predictor of these outcomes, particularly so in patients with severe inflammation. CONCLUSIONS: These data are in keeping with the hypothesis that in systemic inflammation altered E-selectin shedding may play a role in arterial damage and implicates this adhesion molecule in atherosclerotic complications in a high-risk condition like ESRD.
Authors: Mahmut Ilker Yilmaz; Juan Jesús Carrero; Alberto Ortiz; Jose Luis Martín-Ventura; Alper Sonmez; Mutlu Saglam; Halil Yaman; Mujdat Yenicesu; Jesús Egido; Luis Miguel Blanco-Colio Journal: Clin J Am Soc Nephrol Date: 2009-10-09 Impact factor: 8.237
Authors: Carmen A Vlahu; Bregtje A Lemkes; Dirk G Struijk; Marion G Koopman; Raymond T Krediet; Hans Vink Journal: J Am Soc Nephrol Date: 2012-10-18 Impact factor: 10.121
Authors: Xinhui Li; Kory R Johnson; Mark Bryant; Abdel G Elkahloun; Marcelo Amar; Alan T Remaley; Ranil De Silva; John M Hallenbeck; Jacqueline A Quandt Journal: PLoS One Date: 2011-06-20 Impact factor: 3.240
Authors: Sabrina H Rossi; Emily P McQuarrie; William H Miller; Ruth M Mackenzie; Jane A Dymott; María U Moreno; Chiara Taurino; Ashley M Miller; Ulf Neisius; Geoffrey A Berg; Zivile Valuckiene; Jonathan A Hannay; Anna F Dominiczak; Christian Delles Journal: BMC Nephrol Date: 2013-08-13 Impact factor: 2.388