Literature DB >> 1787385

The effect of in vitro irradiation on human NK cell activity. A preliminary report.

J N Halpern1, E Cohen, T Mekori, A N Beny, A Kuten, E A Rosenblatt, E Robinson.   

Abstract

Natural killer activity of peripheral blood cells was evaluated after in vitro irradiation at doses ranging between 100 and 1600 cGy. Natural killer (NK) cells from normal donors exhibited a trend towards increased cytotoxicity peaking at about 600 cGy and then gradually decreasing. NK cells isolated from peripheral blood of cancer patients showed a lower baseline of activity, which was less affected by the same doses of in vitro irradiation. A distinction could be made between patients with early disease and those with advanced cancers; patients with early cancers showing NK activity close to that of normal donors.

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Year:  1991        PMID: 1787385

Source DB:  PubMed          Journal:  J Med        ISSN: 0025-7850


  4 in total

1.  Tumor Therapeutics Work as Stress Inducers to Enhance Tumor Sensitivity to Natural Killer (NK) Cell Cytolysis by Up-regulating NKp30 Ligand B7-H6.

Authors:  Guoshuai Cao; Jian Wang; Xiaodong Zheng; Haiming Wei; Zhigang Tian; Rui Sun
Journal:  J Biol Chem       Date:  2015-10-15       Impact factor: 5.157

Review 2.  Immunomodulatory effects of radiation: what is next for cancer therapy?

Authors:  Anita Kumari; Samantha S Simon; Tomika D Moody; Charlie Garnett-Benson
Journal:  Future Oncol       Date:  2015-12-01       Impact factor: 3.404

3.  Effects of lethal irradiation and cyclosporin A treatment on the growth and tumoricidal activity of a T cell clone potentially useful in cancer therapy.

Authors:  A Cesano; S Visonneau; L Cioé; S C Clark; D Santoli
Journal:  Cancer Immunol Immunother       Date:  1995-03       Impact factor: 6.968

Review 4.  The effect of radiation on the immune response to cancers.

Authors:  Bonggoo Park; Cassian Yee; Kyung-Mi Lee
Journal:  Int J Mol Sci       Date:  2014-01-10       Impact factor: 5.923

  4 in total

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