OBJECTIVE: In order to study the association of G241R polymorphism of ICAM-1 gene with an earlier onset of Graves' disease (GD) and the susceptibility of K469E polymorphism to Graves' ophthalmopathy (GO) in Chinese population. STUDY DESIGN: A case-control and replication study was performed in 212 GD patients and 204 healthy subjects to analyze the genotypes. Furthermore the distribution of ICAM-1 genotypes was investigated in subgroups of patients with GD according to the onset age and the ophthalmopathy. RESULTS: No G241R polymorphism of ICAM-1 gene was detected in Chinese. No significant differences of allele and genotype frequencies regarding K469E polymorphism were found between GD patients and healthy controls (chi2 = 0.092, P = 0.762; chi2 = 1.089, P = 0.580). In addition, the genotype-phenotype correlation was not identified either. CONCLUSIONS: We found no association of G241R and K469E polymorphisms of the ICAM-1gene with the development of GD in a Chinese population. However, we could not rule out possible contributions of other polymorphisms of the ICAM-1gene to the pathogenesis of GD. Therefore, further studies are needed to elucidate the role of ICAM-1gene in Graves' disease in different population.
OBJECTIVE: In order to study the association of G241R polymorphism of ICAM-1 gene with an earlier onset of Graves' disease (GD) and the susceptibility of K469E polymorphism to Graves' ophthalmopathy (GO) in Chinese population. STUDY DESIGN: A case-control and replication study was performed in 212 GDpatients and 204 healthy subjects to analyze the genotypes. Furthermore the distribution of ICAM-1 genotypes was investigated in subgroups of patients with GD according to the onset age and the ophthalmopathy. RESULTS: No G241R polymorphism of ICAM-1 gene was detected in Chinese. No significant differences of allele and genotype frequencies regarding K469E polymorphism were found between GDpatients and healthy controls (chi2 = 0.092, P = 0.762; chi2 = 1.089, P = 0.580). In addition, the genotype-phenotype correlation was not identified either. CONCLUSIONS: We found no association of G241R and K469E polymorphisms of the ICAM-1gene with the development of GD in a Chinese population. However, we could not rule out possible contributions of other polymorphisms of the ICAM-1gene to the pathogenesis of GD. Therefore, further studies are needed to elucidate the role of ICAM-1gene in Graves' disease in different population.
Authors: Sergey Nejentsev; Mikko Laaksonen; Pentti J Tienari; Oscar Fernandez; Heather Cordell; Juhani Ruutiainen; Juhani Wikström; Tomi Pastinen; Satu Kuokkanen; Jan Hillert; Jorma Ilonen Journal: Hum Immunol Date: 2003-03 Impact factor: 2.850
Authors: M Bagnasco; G P Pesce; A Caretto; F Paolieri; C Pronzato; B Villaggio; C Giordano; C Betterle; G W Canonica Journal: J Allergy Clin Immunol Date: 1995-05 Impact factor: 10.793
Authors: P Viganò; M Infantino; D Lattuada; R Lauletta; E Ponti; E Somigliana; M Vignali; A M DiBlasio Journal: Mol Hum Reprod Date: 2003-01 Impact factor: 4.025