OBJECTIVES: To compare the intrinsic activity of pradofloxacin, a new fluoroquinolone developed for use in veterinary medicine, with other fluoroquinolones, against anaerobic bacteria isolated from dogs and cats. METHODS: One hundred and forty-one anaerobes were isolated from dogs and cats and comparative MICs of pradofloxacin, marbofloxacin, enrofloxacin, difloxacin and ibafloxacin were determined according to standardized agar dilution methodology. RESULTS: Pradofloxacin exerted the greatest antibacterial activity followed by marbofloxacin, enrofloxacin, difloxacin and ibafloxacin. Based on the distinctly lower MIC(50), MIC(90) and mode MIC values, pradofloxacin exhibited a higher in vitro activity than any of the comparator fluoroquinolones. CONCLUSIONS: Pradofloxacin, a novel third-generation fluoroquinolone, has broad-spectrum anti-anaerobe activity and offers utility as single-drug therapy for mixed aerobic/anaerobic infections.
OBJECTIVES: To compare the intrinsic activity of pradofloxacin, a new fluoroquinolone developed for use in veterinary medicine, with other fluoroquinolones, against anaerobic bacteria isolated from dogs and cats. METHODS: One hundred and forty-one anaerobes were isolated from dogs and cats and comparative MICs of pradofloxacin, marbofloxacin, enrofloxacin, difloxacin and ibafloxacin were determined according to standardized agar dilution methodology. RESULTS:Pradofloxacin exerted the greatest antibacterial activity followed by marbofloxacin, enrofloxacin, difloxacin and ibafloxacin. Based on the distinctly lower MIC(50), MIC(90) and mode MIC values, pradofloxacin exhibited a higher in vitro activity than any of the comparator fluoroquinolones. CONCLUSIONS:Pradofloxacin, a novel third-generation fluoroquinolone, has broad-spectrum anti-anaerobe activity and offers utility as single-drug therapy for mixed aerobic/anaerobic infections.
Authors: Silpak Biswas; Ricardo G Maggi; Mark G Papich; Daniel Keil; Edward B Breitschwerdt Journal: J Clin Microbiol Date: 2009-12-09 Impact factor: 5.948
Authors: Gregor Hauschild; Karl Rohn; Eva Engelhardt; Martin Sager; Jendrik Hardes; Georg Gosheger Journal: BMC Vet Res Date: 2013-02-14 Impact factor: 2.741
Authors: Gianluca Celani; Serena Maria Rita Tulini; Camilla Montesano; Daniela Zezza; Manuel Sergi; Vincenzo Varasano; Carlo Maria Mortellaro; Dario Compagnone; Michele Amorena; Lucio Petrizzi Journal: Vet Rec Open Date: 2017-09-26