Literature DB >> 17872638

Exposure to sibutramine during pregnancy.

Facundo Garcia-Bournissen, Alon Shrim, Gideon Koren.   

Abstract

QUESTION: One of my patients who was taking sibutramine to lose weight found out that she had unexpectedly conceived. The medication was stopped as soon as she found out, about 5 weeks into the pregnancy. Is the baby at risk? Should the pregnancy be aborted? ANSWER: No data to date suggest that involuntary exposure to sibutramine during pregnancy carries major risk of congenital malformations. Nevertheless, this medication should be avoided whenever possible during pregnancy, as there is little information on its effects.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17872638      PMCID： PMC1949118     

Source DB:  PubMed          Journal:  Can Fam Physician        ISSN： 0008-350X            Impact factor:   3.275


  9 in total

Review 1.  Obesity.

Authors:  Susan Z Yanovski; Jack A Yanovski
Journal:  N Engl J Med       Date:  2002-02-21       Impact factor: 91.245

2.  Exposure to sibutramine during pregnancy: a case series.

Authors:  A Einarson; L Bonari; M Sarkar; K McKenna; G Koren
Journal:  Eur J Obstet Gynecol Reprod Biol       Date:  2004-09-10       Impact factor: 2.435

3.  A clinical trial of the use of sibutramine for the treatment of patients suffering essential obesity.

Authors:  G Fanghänel; L Cortinas; L Sánchez-Reyes; A Berber
Journal:  Int J Obes Relat Metab Disord       Date:  2000-02

Review 4.  Pharmacological and surgical treatments for obesity.

Authors:  Tracy DeWald; Lalita Khaodhiar; Mark P Donahue; George Blackburn
Journal:  Am Heart J       Date:  2006-03       Impact factor: 4.749

5.  Effect of sibutramine on weight maintenance after weight loss: a randomised trial. STORM Study Group. Sibutramine Trial of Obesity Reduction and Maintenance.

Authors:  W P James; A Astrup; N Finer; J Hilsted; P Kopelman; S Rössner; W H Saris; L F Van Gaal
Journal:  Lancet       Date:  2000 Dec 23-30       Impact factor: 79.321

6.  Long-term weight loss with sibutramine: a randomized controlled trial.

Authors:  A Wirth; J Krause
Journal:  JAMA       Date:  2001-09-19       Impact factor: 56.272

7.  Sibutramine use in pregnancy: report of two cases.

Authors:  Mine Kadioglu; Cunay Ulku; Fusun Yaris; Murat Kesim; Nuri Ihsan Kalyoncu; Ersin Yaris
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2004-08

8.  Neural tube defects and maternal weight reduction in early pregnancy.

Authors:  E Robert; C Francannet; G Shaw
Journal:  Reprod Toxicol       Date:  1995 Jan-Feb       Impact factor: 3.143

9.  Early first-trimester sibutramine exposure : pregnancy outcome and neonatal follow-up.

Authors:  Marco De Santis; Gianluca Straface; Anna F Cavaliere; Brigida Carducci; Alessandro Caruso
Journal:  Drug Saf       Date:  2006       Impact factor: 5.606
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.