Literature DB >> 17872605

Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine.

Parvaz Madadi, Gideon Koren, James Cairns, David Chitayat, Andrea Gaedigk, J Steven Leeder, Ronni Teitelbaum, Tatyana Karaskov, Katarina Aleksa.   

Abstract

QUESTION: Recently a newborn died from morphine poisoning when his mother used codeine while breastfeeding. Many patients receive codeine for postlabour pain. Is it safe to prescribe codeine for nursing mothers? ANSWER: When a mother is an ultrarapid metabolizer of cytochrome P450 2D6, she produces much more morphine when taking codeine than most people do. In this situation, newborns might be exposed to toxic levels of morphine when breastfeeding. Options to reduce this risk include discontinuing codeine after 2 to 3 days of use and being aware of symptoms of potential opioid toxicity in both mothers and newborns.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17872605      PMCID： PMC1952551     

Source DB:  PubMed          Journal:  Can Fam Physician        ISSN： 0008-350X            Impact factor:   3.275


  10 in total

Review 1.  Pharmacogenetics and adverse drug reactions.

Authors:  U A Meyer
Journal:  Lancet       Date:  2000-11-11       Impact factor: 79.321

2.  Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans.

Authors:  Andrea Gaedigk; L DiAnne Bradford; Kenda A Marcucci; J Steven Leeder
Journal:  Clin Pharmacol Ther       Date:  2002-07       Impact factor: 6.875

3.  Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother.

Authors:  Gideon Koren; James Cairns; David Chitayat; Andrea Gaedigk; Steven J Leeder
Journal:  Lancet       Date:  2006-08-19       Impact factor: 79.321

Review 4.  Transfer of drugs and other chemicals into human milk.

Authors: 
Journal:  Pediatrics       Date:  2001-09       Impact factor: 7.124

5.  Codeine intoxication associated with ultrarapid CYP2D6 metabolism.

Authors:  Yvan Gasche; Youssef Daali; Marc Fathi; Alberto Chiappe; Silvia Cottini; Pierre Dayer; Jules Desmeules
Journal:  N Engl J Med       Date:  2004-12-30       Impact factor: 91.245

6.  Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication.

Authors:  S Ito; A Blajchman; M Stephenson; C Eliopoulos; G Koren
Journal:  Am J Obstet Gynecol       Date:  1993-05       Impact factor: 8.661

7.  Postoperative pain in the neonate: age-related differences in morphine requirements and metabolism.

Authors:  Nancy J Bouwmeester; Wim C J Hop; Monique van Dijk; K J S Anand; John N van den Anker; Dick Tibboel
Journal:  Intensive Care Med       Date:  2003-07-25       Impact factor: 17.440

8.  A pharmacogenetic study of uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine.

Authors:  Michael B Sawyer; Federico Innocenti; Soma Das; Cheng Cheng; Jacqueline Ramírez; Friedl H Pantle-Fisher; Constance Wright; Judith Badner; Deqing Pei; James M Boyett; Edwin Cook; Mark J Ratain
Journal:  Clin Pharmacol Ther       Date:  2003-06       Impact factor: 6.875

9.  Codeine and the breastfed neonate.

Authors:  R G Meny; E G Naumburg; L S Alger; J L Brill-Miller; S Brown
Journal:  J Hum Lact       Date:  1993-12       Impact factor: 2.219

10.  Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human udp-glucuronosyltransferases: evidence for atypical glucuronidation kinetics by UGT2B7.

Authors:  Andrew N Stone; Peter I Mackenzie; Aleksandra Galetin; J Brian Houston; John O Miners
Journal:  Drug Metab Dispos       Date:  2003-09       Impact factor: 3.922
  10 in total
  36 in total

1.  Baby boy blue - why is this newborn lethargic?

Authors:  Michael Rieder; Gideon Koren
Journal:  Paediatr Child Health       Date:  2010-11       Impact factor: 2.253

Review 2.  The role of pharmacogenetics in nonmalignant gastrointestinal diseases.

Authors:  Michael Camilleri
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2012-02-07       Impact factor: 46.802

Review 3.  ABM clinical protocol #21: guidelines for breastfeeding and substance use or substance use disorder, revised 2015.

Authors:  Sarah Reece-Stremtan; Kathleen A Marinelli
Journal:  Breastfeed Med       Date:  2015-04       Impact factor: 1.817

4.  Morphine in breast milk.

Authors:  Mitch Young
Journal:  Can Fam Physician       Date:  2007-06       Impact factor: 3.275

Review 5.  Back to the Future - Part 2. Post-mortem assessment and evolutionary role of the bio-medicolegal sciences.

Authors:  Santo Davide Ferrara; Giovanni Cecchetto; Rossana Cecchi; Donata Favretto; Silke Grabherr; Takaki Ishikawa; Toshikazu Kondo; Massimo Montisci; Heidi Pfeiffer; Maurizio Rippa Bonati; Dina Shokry; Marielle Vennemann; Thomas Bajanowski
Journal:  Int J Legal Med       Date:  2017-04-25       Impact factor: 2.686

Review 6.  Genetic variability of pain perception and treatment--clinical pharmacological implications.

Authors:  Jörn Lötsch
Journal:  Eur J Clin Pharmacol       Date:  2011-02-23       Impact factor: 2.953

7.  The legacy of Motherisk.

Authors:  Nicholas Pimlott
Journal:  Can Fam Physician       Date:  2020-11       Impact factor: 3.275

8.  Opioid use and lactation: protecting the child in the context of maternal pain care.

Authors:  Beth D Darnall; Michael E Schatman
Journal:  Pain Med       Date:  2015-03-13       Impact factor: 3.750

9.  Establishing causality of CNS depression in breastfed infants following maternal codeine use.

Authors:  Parvaz Madadi; Farshad Shirazi; Frank G Walter; Gideon Koren
Journal:  Paediatr Drugs       Date:  2008       Impact factor: 3.022

Review 10.  Medical and psychological risks and consequences of long-term opioid therapy in women.

Authors:  Beth D Darnall; Brett R Stacey; Roger Chou
Journal:  Pain Med       Date:  2012-08-20       Impact factor: 3.750
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.