Literature DB >> 17872562

The IL23 axis plays a key role in the pathogenesis of IBD.

Dermot McGovern1, Fiona Powrie.   

Abstract

Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17872562      PMCID： PMC2000291          DOI： 10.1136/gut.2006.115402

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  34 in total

1.  Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17.

Authors:  Sudeepta Aggarwal; Nico Ghilardi; Ming-Hong Xie; Frederic J de Sauvage; Austin L Gurney
Journal:  J Biol Chem       Date:  2002-11-03       Impact factor: 5.157

2.  Increased expression of interleukin 17 in inflammatory bowel disease.

Authors:  S Fujino; A Andoh; S Bamba; A Ogawa; K Hata; Y Araki; T Bamba; Y Fujiyama
Journal:  Gut       Date:  2003-01       Impact factor: 23.059

3.  Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.

Authors:  B Oppmann; R Lesley; B Blom; J C Timans; Y Xu; B Hunte; F Vega; N Yu; J Wang; K Singh; F Zonin; E Vaisberg; T Churakova; M Liu; D Gorman; J Wagner; S Zurawski; Y Liu; J S Abrams; K W Moore; D Rennick; R de Waal-Malefyt; C Hannum; J F Bazan; R A Kastelein
Journal:  Immunity       Date:  2000-11       Impact factor: 31.745

4.  Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain.

Authors:  Daniel J Cua; Jonathan Sherlock; Yi Chen; Craig A Murphy; Barbara Joyce; Brian Seymour; Linda Lucian; Wayne To; Sylvia Kwan; Tatyana Churakova; Sandra Zurawski; Maria Wiekowski; Sergio A Lira; Daniel Gorman; Robert A Kastelein; Jonathon D Sedgwick
Journal:  Nature       Date:  2003-02-13       Impact factor: 49.962

Review 5.  The immunological and genetic basis of inflammatory bowel disease.

Authors:  Gerd Bouma; Warren Strober
Journal:  Nat Rev Immunol       Date:  2003-07       Impact factor: 53.106

6.  Analysis of the IBD5 locus and potential gene-gene interactions in Crohn's disease.

Authors:  K Negoro; D P B McGovern; Y Kinouchi; S Takahashi; N J Lench; T Shimosegawa; A Carey; L R Cardon; D P Jewell; D A van Heel
Journal:  Gut       Date:  2003-04       Impact factor: 23.059

7.  CARD15/NOD2 mutational analysis in Japanese patients with Crohn's disease.

Authors:  M Sugimura; Y Kinouchi; S Takahashi; H Aihara; S Takagi; K Negoro; N Obana; Y Kojima; K Matsumoto; T Kikuchi; M Hiroki; S Oomori; T Shimosegawa
Journal:  Clin Genet       Date:  2003-02       Impact factor: 4.438

8.  Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells.

Authors:  Christoph Becker; Stefan Wirtz; Manfred Blessing; Jaana Pirhonen; Dennis Strand; Oliver Bechthold; Julia Frick; Peter R Galle; Ingo Autenrieth; Markus F Neurath
Journal:  J Clin Invest       Date:  2003-09       Impact factor: 14.808

9.  A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.

Authors:  Jochen Hampe; Andre Franke; Philip Rosenstiel; Andreas Till; Markus Teuber; Klaus Huse; Mario Albrecht; Gabriele Mayr; Francisco M De La Vega; Jason Briggs; Simone Günther; Natalie J Prescott; Clive M Onnie; Robert Häsler; Bence Sipos; Ulrich R Fölsch; Thomas Lengauer; Matthias Platzer; Christopher G Mathew; Michael Krawczak; Stefan Schreiber
Journal:  Nat Genet       Date:  2006-12-31       Impact factor: 38.330

10.  Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation.

Authors:  Craig A Murphy; Claire L Langrish; Yi Chen; Wendy Blumenschein; Terrill McClanahan; Robert A Kastelein; Jonathon D Sedgwick; Daniel J Cua
Journal:  J Exp Med       Date:  2003-12-08       Impact factor: 14.307
View more
  81 in total

Review 1.  Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models.

Authors:  Aya M Westbrook; Akos Szakmary; Robert H Schiestl
Journal:  Mutat Res       Date:  2010-03-16       Impact factor: 2.433

2.  Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohn's disease.

Authors:  Travis B Murdoch; Wei Xu; Joanne M Stempak; Carol Landers; Stephan R Targan; Jerome I Rotter; Mark S Silverberg
Journal:  Inflamm Bowel Dis       Date:  2012-01-24       Impact factor: 5.325

Review 3.  Th17 cells: interactions with predisposing factors in the immunopathogenesis of inflammatory bowel disease.

Authors:  Ali Raza; Wajeeha Yousaf; Ralph Giannella; Mohamed Tarek Shata
Journal:  Expert Rev Clin Immunol       Date:  2012-02       Impact factor: 4.473

4.  Polymorphisms of the IL23R gene are associated with psoriasis but not with immunoglobulin A nephropathy in a Hungarian population.

Authors:  Eniko Safrany; Marta Szell; Veronika Csongei; Luca Jaromi; Csilla Sipeky; Titanilla Szabo; Lajos Kemeny; Judit Nagy; Bela Melegh
Journal:  Inflammation       Date:  2011-12       Impact factor: 4.092

Review 5.  Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases.

Authors:  Daniel A Peterson; Daniel N Frank; Norman R Pace; Jeffrey I Gordon
Journal:  Cell Host Microbe       Date:  2008-06-12       Impact factor: 21.023

Review 6.  Resolution of Crohn's disease.

Authors:  Heike Schmitt; Clemens Neufert; Markus F Neurath; Raja Atreya
Journal:  Semin Immunopathol       Date:  2019-09-24       Impact factor: 9.623

7.  Contribution of rs11465788 in IL23R gene to Crohn's disease susceptibility and phenotype in Chinese population.

Authors:  Chen Bin; Zeng Zhirong; Wu Xiaoqin; Chen Minhu; Li Mei; Gao Xiang; Chen Baili; Hu Pinjin
Journal:  J Genet       Date:  2009-08       Impact factor: 1.166

8.  IL23R haplotypes provide a large population attributable risk for Crohn's disease.

Authors:  Kent D Taylor; Stephan R Targan; Ling Mei; Andrew F Ippoliti; Dermot McGovern; Emebet Mengesha; Lily King; Jerome I Rotter
Journal:  Inflamm Bowel Dis       Date:  2008-09       Impact factor: 5.325

9.  Activation of signal transducer and activator of transcription-1 (STAT-1) and differential expression of interferon-gamma and anti-inflammatory proteins in pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposis.

Authors:  R F Leal; M L S Ayrizono; M Milanski; A Coope; J J Fagundes; L A Velloso; C S R Coy
Journal:  Clin Exp Immunol       Date:  2010-03-16       Impact factor: 4.330

10.  Regulation of IL12B Expression in Human Macrophages by TALEN-mediated Epigenome Editing.

Authors:  Meng Chen; Hua Zhu; Yu-Juan Mao; Nan Cao; Ya-Li Yu; Lian-Yun Li; Qiu Zhao; Min Wu; Mei Ye
Journal:  Curr Med Sci       Date:  2020-10-29
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.