| Literature DB >> 17869513 |
Ping Chen1, Charles G Caldwell, Robert J Mathvink, Barbara Leiting, Frank Marsilio, Reshma A Patel, Joseph K Wu, Huaibing He, Kathryn A Lyons, Nancy A Thornberry, Ann E Weber.
Abstract
A series of substituted imidazopiperidine amides has been prepared and evaluated for inhibition of dipeptidyl peptidase IV (DPP-4). Substitution at the 1- and 3-positions produced increased selectivity for DPP-4 relative to DPP-8 and DPP-9. Compounds in this series had IC(50) values as low as 5.8 nM for inhibition of DPP-4.Entities:
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Year: 2007 PMID： 17869513 DOI： 10.1016/j.bmcl.2007.08.030
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823