| Literature DB >> 17869512 |
Johann Leban1, Marcel Baierl, Jan Mies, Viola Trentinaglia, Sandra Rath, Kerstin Kronthaler, Kristina Wolf, Astrid Gotschlich, Markus H J Seifert.
Abstract
A novel class of NF-kappaB pathway signaling inhibitors was discovered by virtual screening, medicinal chemistry, and QSAR analysis. An initial set of compounds inhibited NF-kappaB signaling in a whole cell reporter gene assay in the micro-molar range. Activity was improved step by step by medicinal chemistry to yield nano-molar signaling inhibitors.Entities:
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Year: 2007 PMID： 17869512 DOI： 10.1016/j.bmcl.2007.08.022
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823