Literature DB >> 17869509

Amino-caprolactam derivatives as gamma-secretase inhibitors.

Michael F Parker1, Joanne J Bronson, Donna M Barten, Jason A Corsa, Wengsheng Du, Kevin M Felsenstein, Valerie L Guss, Darcy Izzarelli, Alice Loo, Kate E McElhone, Larry R Marcin, Ramesh Padmanabha, Roger Pak, Craig T Polson, Jeremy H Toyn, Sam Varma, Jian Wang, Victoria Wong, Ming Zheng, Susan B Roberts.   

Abstract

A series of amino-caprolactam sulfonamides were developed from a screening hit. Compounds with good in vitro and in vivo gamma-secretase activity are reported.

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Year:  2007        PMID: 17869509     DOI: 10.1016/j.bmcl.2007.08.047

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor.

Authors:  Kevin W Gillman; John E Starrett; Michael F Parker; Kai Xie; Joanne J Bronson; Lawrence R Marcin; Kate E McElhone; Carl P Bergstrom; Robert A Mate; Richard Williams; Jere E Meredith; Catherine R Burton; Donna M Barten; Jeremy H Toyn; Susan B Roberts; Kimberley A Lentz; John G Houston; Robert Zaczek; Charles F Albright; Carl P Decicco; John E Macor; Richard E Olson
Journal:  ACS Med Chem Lett       Date:  2010-03-22       Impact factor: 4.345

  1 in total

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