Literature DB >> 17869104

Discovery of potent T-type calcium channel blocker.

Han Na Seo1, Ja Youn Choi, Yun Jeong Choe, Yoonjee Kim, Hyewhon Rhim, So Ha Lee, Jungahn Kim, Dong Jun Joo, Jae Yeol Lee.   

Abstract

The intensive SAR study of 3,4-dihydroquinazoline series led to the most potent compound 10 (KYS05090: IC(50)=41+/-1 nM) against T-type calcium channel and its potency is nearly comparable to that of Kurtoxin. As a small organic molecule, this compound showed the highest blocking activity reported to date.

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Year:  2007        PMID： 17869104     DOI： 10.1016/j.bmcl.2007.08.070

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Identification of 'Voodoo': an emerging substance of abuse in Egypt.

Authors:  Rania Hussien; Sarah Ahmed; Hanem Awad; Maged El-Setouhy; Mohamed El-Shinawi; Jon Mark Hirshon
Journal:  Int J Environ Anal Chem       Date:  2020-01-16       Impact factor: 2.826

2.  Friedel-Crafts synthesis of bis(trifluoromethylated)-4-aryl-3,4-dihydroquinazolines, bis(trifluoromethylated)-3,4-dihydroquinazoline-4-ols and trifluoromethyl arylketoimines using N-aryltrifluoroacetimidoyl chlorides and benzene derivatives.

Authors:  Elham Kazemi; Ali Darehkordi; Alireza Abbasi
Journal:  Mol Divers       Date:  2021-02-03       Impact factor: 2.943

3.  In silico identification of T-type calcium channel blockers: A ligand-based pharmacophore mapping approach.

Authors:  Tamanna Gandhi; Anu R Melge; C Gopi Mohan
Journal:  J Adv Res       Date:  2016-09-16       Impact factor: 10.479

4.  Microwave Assisted Synthesis of 4-Phenylquinazolin-2(1H)-one Derivatives that Inhibit Vasopressor Tonus in Rat Thoracic Aorta.

Authors:  Rafaela Teixeira; Talita Menengat; Gabriel Andrade; Bruno Cotrim; Cristiano Ponte; Wilson C Santos; Gabriel Resende
Journal:  Molecules       Date:  2020-03-24       Impact factor: 4.411
  4 in total

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