| Literature DB >> 17868855 |
Barbara J Bain1, Sarah H Fletcher.
Abstract
Among patients with hypereosinophilia, a myeloproliferative variant is recognized. In many of these patients a diagnosis of eosinophilic leukemia can be made. The molecular mechanism is often a fusion gene, incorporating part of PDGFRA or PDGFRB, encoding anaberrant tyrosine kinase. Prompt diagnosis of such cases is important since specific tyrosine kinase inhibitor therapy is indicated.Entities:
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Year: 2007 PMID： 17868855 DOI： 10.1016/j.iac.2007.06.001
Source DB: PubMed Journal: Immunol Allergy Clin North Am ISSN： 0889-8561 Impact factor: 3.479