OBJECTIVE: To see the toxic effects of NSAID on kidney tissue of albino rats. METHODS: For this experimental study, 16 albino rats were taken. They were divided into two groups; A and B. The animals in group-A were given Normal Saline. Group-B received Diclofenac Sodium 2 mg/kg/day by feeding tube for 14 days. On day-15 all animals were sacrificed. Kidneys were removed, fixed, embedded in paraffin, section cut at 4 microm thick and stained with H&E, PAS, and silver methenamine. Renal histology was done under light microscope to see the renal tubular diameter, count and cellular detail. RESULTS: The result of present study revealed that diclofenac sodium in single daily dose of 2 mg/kg for a period of two weeks effectively produced destruction of proximal and distal convoluted tubules in adult albino rats showing the dilatation of tubule and flattening of tubular epithelium, disruption of brush border in proximal tubule and thickening of basement membrane around proximal and distal tubular epithelium. CONCLUSION: Diclofenac sodium induced nephrotoxicity causes the destruction of proximal and distal convoluted tubules showing the dilatation of tubule and flattening of its epithelium in albino rats.
OBJECTIVE: To see the toxic effects of NSAID on kidney tissue of albino rats. METHODS: For this experimental study, 16 albino rats were taken. They were divided into two groups; A and B. The animals in group-A were given Normal Saline. Group-B received Diclofenac Sodium 2 mg/kg/day by feeding tube for 14 days. On day-15 all animals were sacrificed. Kidneys were removed, fixed, embedded in paraffin, section cut at 4 microm thick and stained with H&E, PAS, and silver methenamine. Renal histology was done under light microscope to see the renal tubular diameter, count and cellular detail. RESULTS: The result of present study revealed that diclofenac sodium in single daily dose of 2 mg/kg for a period of two weeks effectively produced destruction of proximal and distal convoluted tubules in adult albino rats showing the dilatation of tubule and flattening of tubular epithelium, disruption of brush border in proximal tubule and thickening of basement membrane around proximal and distal tubular epithelium. CONCLUSION:Diclofenac sodium induced nephrotoxicity causes the destruction of proximal and distal convoluted tubules showing the dilatation of tubule and flattening of its epithelium in albino rats.
Authors: Ahmed Abdelmoniem Mousa; Ahmed Essam Elweza; Hamed Talaat Elbaz; Enas Abd El-Aziz Tahoun; Khaled Mohamed Shoghy; Islam Elsayed; El Barbary Hassan Journal: J Tradit Complement Med Date: 2019-11-25