Literature DB >> 1786548

Expression of APP in the early stage of brain damage.

T Kawarabayashi1, M Shoji, Y Harigaya, H Yamaguchi, S Hirai.   

Abstract

We immunocytochemically studied the expression of various epitopes of amyloid beta/A4 protein precursor (APP) after brain damage by kainic acid injection. After 3 h, APP695 rapidly accumulated in dystrophic neurites near the damaged site. After 3 days, APP with Kunitz-type protease inhibitor domain was expressed in reactive astrocytes in the lesion and ipsilateral hippocampus. APP rapidly accumulated in dystrophic neurites, and different types of APP were expressed in different cell types in the damaged brain.

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Year:  1991        PMID： 1786548     DOI： 10.1016/0006-8993(91)91558-i

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  21 in total

1.  Real-time PCR quantitation of FE65 a beta-amyloid precursor protein-binding protein after traumatic brain injury in rats.

Authors:  Morio Iino; Masato Nakatome; Yoshiaki Ogura; Harutoshi Fujimura; Hisanaga Kuroki; Hiromasa Inoue; Yukiko Ino; Tasuku Fujii; Toshiyuki Terao; Ryoji Matoba
Journal:  Int J Legal Med       Date:  2003-04-18       Impact factor: 2.686

2.  Combination treatment of experimental stroke with Niaspan and Simvastatin, reduces axonal damage and improves functional outcome.

Authors:  Amjad Shehadah; Jieli Chen; Xu Cui; Cynthia Roberts; Mei Lu; Michael Chopp
Journal:  J Neurol Sci       Date:  2010-05-07       Impact factor: 3.181

Review 3.  Ion channel hypothesis for Alzheimer amyloid peptide neurotoxicity.

Authors:  H B Pollard; N Arispe; E Rojas
Journal:  Cell Mol Neurobiol       Date:  1995-10       Impact factor: 5.046

Review 4.  Traumatic brain injury: cause or risk of Alzheimer's disease? A review of experimental studies.

Authors:  J Szczygielski; A Mautes; W I Steudel; P Falkai; T A Bayer; O Wirths
Journal:  J Neural Transm (Vienna)       Date:  2005-06-15       Impact factor: 3.575

Review 5.  Adrenal steroids and plasticity of hippocampal neurons: toward an understanding of underlying cellular and molecular mechanisms.

Authors:  B S McEwen; H Cameron; H M Chao; E Gould; A M Magarinos; Y Watanabe; C S Woolley
Journal:  Cell Mol Neurobiol       Date:  1993-08       Impact factor: 5.046

6.  Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease.

Authors:  G W Roberts; S M Gentleman; A Lynch; L Murray; M Landon; D I Graham
Journal:  J Neurol Neurosurg Psychiatry       Date:  1994-04       Impact factor: 10.154

7.  Molecular pathology of Alzheimer's disease.

Authors:  M N Rossor
Journal:  J Neurol Neurosurg Psychiatry       Date:  1993-06       Impact factor: 10.154

Review 8.  The role of beta-amyloid peptide in Alzheimer's disease.

Authors:  A LeBlanc
Journal:  Metab Brain Dis       Date:  1994-03       Impact factor: 3.584

9.  Altered processing of Alzheimer amyloid precursor protein in response to neuronal degeneration.

Authors:  K Iverfeldt; S I Walaas; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-01       Impact factor: 11.205

10.  Marked increase of beta-amyloid(1-42) and amyloid precursor protein in ventricular cerebrospinal fluid after severe traumatic brain injury.

Authors:  Annika Olsson; Ludvig Csajbok; Martin Ost; Kina Höglund; Karin Nylén; Lars Rosengren; Bengt Nellgård; Kaj Blennow
Journal:  J Neurol       Date:  2004-07       Impact factor: 4.849
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