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Literature DB >> 1786079

Extrathymic differentiation of intraepithelial lymphocytes: generation of a separate and unequal T-cell repertoire?

Abstract

A significant number of intraepithelial intestinal T cells appear to mature extrathymically. In this paper, Leo Lefrançois discusses the implication of this for T-cell receptor selection and repertoire generation. He goes on to develop the concept that such cells may constitute discrete subsets of organ-specific lymphocytes, with unique T-cell receptor repertoires that may be evolutionary antecedents of thymus-derived T cells.

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Year: 1991 PMID： 1786079 DOI： 10.1016/0167-5699(91)90015-L

Source DB: PubMed Journal: Immunol Today ISSN： 0167-5699

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Cited

23 in total

1. Development of CD8 alpha/beta + TCR alpha beta intestinal intraepithelial lymphocytes in athymic nu/nu mice and participation in regional immune responses.

Authors: M Emoto; Y Emoto; S H Kaufmann
Journal: Immunology Date: 1996-08 Impact factor: 7.397

2. The T cell receptor repertoire of intestinal intraepithelial gammadelta T lymphocytes is influenced by genes linked to the major histocompatibility complex and to the T cell receptor loci.

Authors: P Pereira; J J Lafaille; D Gerber; S Tonegawa
Journal: Proc Natl Acad Sci U S A Date: 1997-05-27 Impact factor: 11.205

3. Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence.

Authors: Momoko Yoshimoto; Prashanth Porayette; Nicole L Glosson; Simon J Conway; Nadia Carlesso; Angelo A Cardoso; Mark H Kaplan; Mervin C Yoder
Journal: Blood Date: 2012-03-19 Impact factor: 22.113

4. Cytolytic activity of intestinal intraepithelial lymphocytes in germ-free mice is strain dependent and determined by T cells expressing gamma delta T-cell antigen receptors.

Authors: M Kawaguchi; M Nanno; Y Umesaki; S Matsumoto; Y Okada; Z Cai; T Shimamura; Y Matsuoka; M Ohwaki; H Ishikawa
Journal: Proc Natl Acad Sci U S A Date: 1993-09-15 Impact factor: 11.205

5. Gut intraepithelial lymphocytes induce immunity against Cryptosporidium infection through a mechanism involving gamma interferon production.

Authors: R J Culshaw; G J Bancroft; V McDonald
Journal: Infect Immun Date: 1997-08 Impact factor: 3.441

6. Characterization of CD8+ T cells and microenvironment in oral lesions of human immunodeficiency virus-infected persons with oropharyngeal candidiasis.

Authors: Kelly M McNulty; Jananya Plianrungsi; Janet E Leigh; Donald Mercante; Paul L Fidel
Journal: Infect Immun Date: 2005-06 Impact factor: 3.441

Extrathymic differentiation of intraepithelial lymphocytes: generation of a separate and unequal T-cell repertoire?

1. Development of CD8 alpha/beta + TCR alpha beta intestinal intraepithelial lymphocytes in athymic nu/nu mice and participation in regional immune responses.

2. The T cell receptor repertoire of intestinal intraepithelial gammadelta T lymphocytes is influenced by genes linked to the major histocompatibility complex and to the T cell receptor loci.

3. Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence.

4. Cytolytic activity of intestinal intraepithelial lymphocytes in germ-free mice is strain dependent and determined by T cells expressing gamma delta T-cell antigen receptors.

5. Gut intraepithelial lymphocytes induce immunity against Cryptosporidium infection through a mechanism involving gamma interferon production.

6. Characterization of CD8+ T cells and microenvironment in oral lesions of human immunodeficiency virus-infected persons with oropharyngeal candidiasis.

Review 7. Development, Homeostasis, and Functions of Intestinal Intraepithelial Lymphocytes.

8. Characterization of bronchoalveolar lavage T cell subsets in sarcoidosis on the basis of CD57, CD4 and CD8.

9. Effect of chronic graft-versus-host disease on the intestine in adult BDF1 mice.

10. T-cell receptor V delta gene usage by tumour reactive gamma delta T lymphocytes infiltrating human lung cancer.