Literature DB >> 1786074

Expression of perforin and granzymes in vivo: potential diagnostic markers for activated cytotoxic cells.

G M Griffiths1, C Mueller.   

Abstract

Perforin and granzymes are considered to be instrumental in cell-mediated cytolysis by cytotoxic T cells and natural killer cells. Here, Gillian Griffiths and Christoph Mueller describe the expression of perforin and granzymes, emphasizing studies in vivo, and discuss the possibility that these proteins are useful diagnostic markers for immune responses involving cytolytic cells.

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Year:  1991        PMID： 1786074     DOI： 10.1016/0167-5699(91)90145-J

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  25 in total

1.  Expression of perforin in nasal lymphoma. Additional evidence of its natural killer cell derivation.

Authors:  N Mori; Y Yatabe; K Oka; T Kinoshita; T Kobayashi; T Ono; J Asai
Journal:  Am J Pathol       Date:  1996-08       Impact factor: 4.307

2.  Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease.

Authors:  S Müller; J Lory; N Corazza; G M Griffiths; K Z'graggen; L Mazzucchelli; A Kappeler; C Mueller
Journal:  Am J Pathol       Date:  1998-01       Impact factor: 4.307

3.  Detection of perforin and tumour necrosis factor alpha mRNA expressing cells in sclerosing lymphocytic lobulitis of the breast.

Authors:  R E Hunger; M Hristic; C Mueller; A Kappeler; H J Altermatt
Journal:  J Clin Pathol       Date:  1997-04       Impact factor: 3.411

4.  Constitutive activation of Lck and Fyn tyrosine kinases in large granular lymphocytes infected with the gamma-herpesvirus agents of malignant catarrhal fever.

Authors:  S Swa; H Wright; J Thomson; H Reid; D Haig
Journal:  Immunology       Date:  2001-01       Impact factor: 7.397

5.  Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in giardiasis.

Authors:  G Oberhuber; H Vogelsang; M Stolte; S Muthenthaler; J A Kummer; A J Kummer; T Radaszkiewicz
Journal:  Am J Pathol       Date:  1996-05       Impact factor: 4.307

6.  Characterization of the host immune response in human Ganglia after herpes zoster.

Authors:  Kavitha Gowrishankar; Megan Steain; Anthony L Cunningham; Michael Rodriguez; Peter Blumbergs; Barry Slobedman; Allison Abendroth
Journal:  J Virol       Date:  2010-06-23       Impact factor: 5.103

Review 7.  Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction?

Authors:  S Gay; R E Gay; W J Koopman
Journal:  Ann Rheum Dis       Date:  1993-03       Impact factor: 19.103

8.  Localization and identification of granzymes A and B-expressing cells in normal human lymphoid tissue and peripheral blood.

Authors:  J A Kummer; A M Kamp; T M Tadema; W Vos; C J Meijer; C E Hack
Journal:  Clin Exp Immunol       Date:  1995-04       Impact factor: 4.330

9.  Expression of intercellular adhesion molecule-1 in murine hearts with acute myocarditis caused by coxsackievirus B3.

Authors:  Y Seko; H Matsuda; K Kato; Y Hashimoto; H Yagita; K Okumura; Y Yazaki
Journal:  J Clin Invest       Date:  1993-04       Impact factor: 14.808

10.  Perforin expression by thyroid-infiltrating T cells in autoimmune thyroid disease.

Authors:  Z Wu; E R Podack; J M McKenzie; K J Olsen; M Zakarija
Journal:  Clin Exp Immunol       Date:  1994-12       Impact factor: 4.330
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