Spermatids are regulators of Sertoli cell function.

Spermatids are major regulators of Sertoli cell function. Specific anatomical structures exist between spermatids and Sertoli cells. Their nature evolves during spermiogenesis and they are essential mediators in the interaction between these two cell types. Spermatids play a crucial role in Sertoli cell gene expression and secretory function at different ages. Early spermatid effect is partly mediated through the secretion of soluble factor(s). The influence of late spermatids on Sertoli cell secretion in the adult testis is conserved throughout evolution and may be mediated via their implication in the conformational changes on Sertoli cells that occur during spermatogenesis and through phagocytosis of the residual bodies.