| Literature DB >> 1785769 |
M P Hardy1, S J Gelber, Z F Zhou, T M Penning, J W Ricigliano, V K Ganjam, D Nonneman, L L Ewing.
Abstract
Leydig cell progenitors contain significant concentrations of androgen receptors. When the metabolism of DHT to 3 alpha-DIOL is blocked, DHT stimulates testosterone production by Leydig cell progenitors, most probably via an androgen receptor dependent mechanism. Rapid metabolism by 3 alpha-HSD may limit the potency of exogenous DHT to stimulate differentiation of Leydig cell progenitors in vitro. Insulin-like growth factor-I enhances androgen production by purified immature Leydig cells. The elevated sensitivity of immature Leydig cells versus adult Leydig cells to IGF-I stimulation indicates that this peptide hormone has a role in their differentiation during puberty.Entities:
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Year: 1991 PMID： 1785769 DOI： 10.1111/j.1749-6632.1991.tb27308.x
Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691