Literature DB >> 17855092

Synthesis and identification of novel 11beta-aryl-4',5'-dihydrospiro[estra-4,9-diene-17beta,4'-oxazole] analogs with dissociated antiprogesterone activities.

Chunyang Jin1, G Manikumar, John A Kepler, C Edgar Cook, George F Allan, Margaret Kiddoe, Sheela Bhattacharjee, Olivia Linton, Scott G Lundeen, Zhihua Sui.   

Abstract

A series of novel 11beta-aryl-4',5'-dihydrospiro[estra-4,9-diene-17beta,4'-oxazole] analogs have been evaluated for their antagonist hormonal properties using the T47D cell-based alkaline phosphatase assay and the A549 cell-based functional assay. Some of the compounds showed highly potent, and more selective antiprogestational activity against antiglucocorticoid activity than mifepristone (RU 486).

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Year:  2007        PMID： 17855092     DOI： 10.1016/j.bmcl.2007.08.064

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Mifepristone increases gamma-retroviral infection efficiency by enhancing the integration of virus into the genome of infected cells.

Authors:  V Solodushko; B Fouty
Journal:  Gene Ther       Date:  2010-05-20       Impact factor: 5.250

2.  Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity.

Authors:  Aaron DeBono; David R Thomas; Lindsay Lundberg; Chelsea Pinkham; Ying Cao; J Dinny Graham; Christine L Clarke; Kylie M Wagstaff; Sharon Shechter; Kylene Kehn-Hall; David A Jans
Journal:  Sci Rep       Date:  2019-02-22       Impact factor: 4.379

3.  Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives.

Authors:  Saloni Kakkar; Sanjiv Kumar; Siong Meng Lim; Kalavathy Ramasamy; Vasudevan Mani; Syed Adnan Ali Shah; Balasubramanian Narasimhan
Journal:  Chem Cent J       Date:  2018-12-04       Impact factor: 4.215

4.  StackPR is a new computational approach for large-scale identification of progesterone receptor antagonists using the stacking strategy.

Authors:  Nalini Schaduangrat; Nuttapat Anuwongcharoen; Mohammad Ali Moni; Pietro Lio'; Phasit Charoenkwan; Watshara Shoombuatong
Journal:  Sci Rep       Date:  2022-09-30       Impact factor: 4.996
  4 in total

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