Literature DB >> 17852462

Fixed dose prothrombin complex concentrate for the reversal of oral anticoagulation therapy.

P Junagade1, R Grace, P Gover.   

Abstract

Warfarin reversal is frequently required in day to day haematology practice. Prothrombin complex concentrates (PCC) have replaced fresh frozen plasma as the agent of choice in warfarin reversal due to its safety profile. Ideal dose of PCC is still not known and many centres have local guidelines on using the product. We have successfully used PCC (Beriplex) at a fixed dose in our hospital, but we still need randomised control trials to identify the ideal dose of PCC which can result in rapid reversal of warfarin with minimum risk of thrombosis.

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Year:  2007        PMID： 17852462     DOI： 10.1080/10245330701448529

Source DB:  PubMed          Journal:  Hematology        ISSN： 1024-5332            Impact factor:   2.269


  7 in total

1.  An unexpected case of coumarin poisoning with coumatetralyl.

Authors:  Amin Kay; Leo Chiu; Christopher A K Y Chong
Journal:  BMJ Case Rep       Date:  2011-04-13

2.  Fast point-of-care coagulometer guided reversal of oral anticoagulation at the bedside hastens management of acute subdural hemorrhage.

Authors:  Timolaos Rizos; Ekkehart Jenetzky; Christian Herweh; Andreas Unterberg; Werner Hacke; Roland Veltkamp
Journal:  Neurocrit Care       Date:  2010-12       Impact factor: 3.210

Review 3.  Fixed-dose 4-factor prothrombin complex concentrate: we don't know where we're going if we don't know how to get there.

Authors:  Scott T Hall; Kyle C Molina
Journal:  J Thromb Thrombolysis       Date:  2018-07       Impact factor: 2.300

4.  Low-dose compared to manufacturer-recommended dose four-factor prothrombin complex concentrate for acute warfarin reversal.

Authors:  Wesley Zemrak; Francis Manuel; Kathryn E Smith; Stephen Rolfe; Timothy Hayes; Robert L Trowbridge; Brian Carlone; David Seder
Journal:  J Thromb Thrombolysis       Date:  2019-02       Impact factor: 2.300

5.  Activated prothrombin complex concentrate factor VIII inhibitor bypassing activity (FEIBA) for the reversal of warfarin-induced coagulopathy.

Authors:  Cezary Wójcik; Michelle L Schymik; Eric G Cure
Journal:  Int J Emerg Med       Date:  2009-11-26

6.  Emergency reversal of antithrombotic treatment.

Authors:  Marcel Levi
Journal:  Intern Emerg Med       Date:  2008-11-12       Impact factor: 3.397

7.  Prothrombin complex concentrate (Beriplex P/N) in severe bleeding: experience in a large tertiary hospital.

Authors:  David Bruce; Tim J C Nokes
Journal:  Crit Care       Date:  2008-08-15       Impact factor: 9.097
  7 in total

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