PURPOSE: To estimate retrospectively the rate of isolated nodal failures (INF) in NSCLC patients treated with the elective nodal irradiation (ENI) using 3D-conformal radiotherapy (3D-CRT). MATERIALS/ METHODS: One hundred and eighty-five patients with I-IIIB stage treated with 3D-CRT in consecutive clinical trials differing in an extent of the ENI were analyzed. According to the extent of the ENI, two groups were distinguished: extended (n = 124) and limited (n = 61) ENI. INF was defined as regional nodal failure occurring without local progression. Cumulative Incidence of INF (CIINF) was evaluated by univariate and multivariate analysis with regard to prognostic factors. RESULTS: With a median follow up of 30 months, the two-year actuarial overall survival was 35%. The two-year CIINF rate was 12%. There were 16 (9%) INF, eight (6%) for extended and eight (13%) for limited ENI. In the univariate analysis bulky mediastinal disease (BMD), left side, higher N stage, and partial response to RT had a significant negative impact on the CIINF. BMD was the only independent predictor of the risk of incidence of the INF (p = 0.001). CONCLUSIONS: INF is more likely to occur in case of more advanced nodal status.
PURPOSE: To estimate retrospectively the rate of isolated nodal failures (INF) in NSCLCpatients treated with the elective nodal irradiation (ENI) using 3D-conformal radiotherapy (3D-CRT). MATERIALS/ METHODS: One hundred and eighty-five patients with I-IIIB stage treated with 3D-CRT in consecutive clinical trials differing in an extent of the ENI were analyzed. According to the extent of the ENI, two groups were distinguished: extended (n = 124) and limited (n = 61) ENI. INF was defined as regional nodal failure occurring without local progression. Cumulative Incidence of INF (CIINF) was evaluated by univariate and multivariate analysis with regard to prognostic factors. RESULTS: With a median follow up of 30 months, the two-year actuarial overall survival was 35%. The two-year CIINF rate was 12%. There were 16 (9%) INF, eight (6%) for extended and eight (13%) for limited ENI. In the univariate analysis bulky mediastinal disease (BMD), left side, higher N stage, and partial response to RT had a significant negative impact on the CIINF. BMD was the only independent predictor of the risk of incidence of the INF (p = 0.001). CONCLUSIONS: INF is more likely to occur in case of more advanced nodal status.
Authors: Aparna H Kesarwala; Christine J Ko; Holly Ning; Eric Xanthopoulos; Karl E Haglund; William P O'Meara; Charles B Simone; Ramesh Rengan Journal: Clin Lung Cancer Date: 2014-12-09 Impact factor: 4.785
Authors: Michał Spych; Leszek Gottwald; Małgorzata Klonowicz; Michał Biegała; Robert Bibik; Jacek Fijuth Journal: Arch Med Sci Date: 2010-10-26 Impact factor: 3.318