Literature DB >> 17851678

Mutational analysis of ErbB2 intracellular localization.

Liyong Chen1, Lu Qian, Zhiyi Zhang, Ming Shi, Yuhua Song, Guogang Yuan, Hao Zhang, Meiru Hu, Ming Yu, Xuemin Zhang, Beifen Shen, Ning Guo.   

Abstract

In the present study, the sub-cellular localization of ErbB2 and its mutants expressed as GFP-tagged proteins in MCF-7 cells or endogenous ErbB2 in SKBR3 cells was examined. The data presented here demonstrate that the full-length ErbB2 was localized at the cytoplasmic membrane and ErbB2 ICD localized in the nucleus predominantly. The sequence of ErbB2 ICD contains the information supporting its nuclear translocation and cytoplasmic retention. A region (residues 721-970) harboring an arginine triplet is essential for the cytoplasmic trafficking of ErbB2. The results indicate that differential sub-cellular localization of ErbB2 ICD and the full-length ErbB2 is dependent on their structural determinants. The present results give initial clues for further analysis of the mechanism of ErbB2 intracellular localization.

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Year:  2007        PMID： 17851678     DOI： 10.1007/s00418-007-0329-z

Source DB:  PubMed          Journal:  Histochem Cell Biol        ISSN： 0948-6143            Impact factor:   4.304


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