Literature DB >> 17851621

N-Methyl substituted 2',4'- BNANC: a highly nuclease-resistant nucleic acid analogue with high-affinity RNA selective hybridization.

Kazuyuki Miyashita1, S M Abdur Rahman, Sayori Seki, Satoshi Obika, Takeshi Imanishi.   

Abstract

Oligonucleotides modified with a novel BNA analogue, 2', 4'-BNA(NC)[N-Me], were synthesized, and in comparison to 2',4'-BNA (LNA), have similarly high RNA affinity, better RNA selectivity and much higher resistance to nuclease degradation, suggesting that the novel BNA analogue may be particularly useful for antisense approaches.

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Year:  2007        PMID： 17851621     DOI： 10.1039/b707352f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  Evaluation of multiple-turnover capability of locked nucleic acid antisense oligonucleotides in cell-free RNase H-mediated antisense reaction and in mice.

Authors:  Tsuyoshi Yamamoto; Naoko Fujii; Hidenori Yasuhara; Shunsuke Wada; Fumito Wada; Naoya Shigesada; Mariko Harada-Shiba; Satoshi Obika
Journal:  Nucleic Acid Ther       Date:  2014-04-23       Impact factor: 5.486

2.  BNANC Gapmers Revert Splicing and Reduce RNA Foci with Low Toxicity in Myotonic Dystrophy Cells.

Authors:  Kassie S Manning; Ashish N Rao; Miguel Castro; Thomas A Cooper
Journal:  ACS Chem Biol       Date:  2017-09-05       Impact factor: 5.100

3.  Superior Silencing by 2',4'-BNA(NC)-Based Short Antisense Oligonucleotides Compared to 2',4'-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors.

Authors:  Tsuyoshi Yamamoto; Hidenori Yasuhara; Fumito Wada; Mariko Harada-Shiba; Takeshi Imanishi; Satoshi Obika
Journal:  J Nucleic Acids       Date:  2012-09-26

4.  Cholesterol-lowering Action of BNA-based Antisense Oligonucleotides Targeting PCSK9 in Atherogenic Diet-induced Hypercholesterolemic Mice.

Authors:  Tsuyoshi Yamamoto; Mariko Harada-Shiba; Moeka Nakatani; Shunsuke Wada; Hidenori Yasuhara; Keisuke Narukawa; Kiyomi Sasaki; Masa-Aki Shibata; Hidetaka Torigoe; Tetsuji Yamaoka; Takeshi Imanishi; Satoshi Obika
Journal:  Mol Ther Nucleic Acids       Date:  2012-05-15       Impact factor: 10.183

5.  A bridged nucleic acid, 2',4'-BNA COC: synthesis of fully modified oligonucleotides bearing thymine, 5-methylcytosine, adenine and guanine 2',4'-BNA COC monomers and RNA-selective nucleic-acid recognition.

Authors:  Yasunori Mitsuoka; Tetsuya Kodama; Ryo Ohnishi; Yoshiyuki Hari; Takeshi Imanishi; Satoshi Obika
Journal:  Nucleic Acids Res       Date:  2009-01-09       Impact factor: 16.971

6.  Inhibitory Effect of Bridged Nucleosides on Thermus aquaticus DNA Polymerase and Insight into the Binding Interactions.

Authors:  Sung-Kun Kim; Aaron Castro; Edward S Kim; Austin P Dinkel; Xiaoyun Liu; Miguel Castro
Journal:  PLoS One       Date:  2016-01-28       Impact factor: 3.240

Review 7.  Development of Antisense Drugs for Dyslipidemia.

Authors:  Tsuyoshi Yamamoto; Fumito Wada; Mariko Harada-Shiba
Journal:  J Atheroscler Thromb       Date:  2016-07-27       Impact factor: 4.928
  7 in total

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