| Literature DB >> 17851411 |
Helmut Rosemeyer1, Martina Anders, Frank Seela.
Abstract
Liquid-liquid phase transfer alkylation of 4-methoxy-pyrazolo[3,4-d]-pyrimidine (1a) with a dichloromethane/dibromomethane mixture (3:1, v/v) gave the regioisomeric methylenebis(heterocycles) 3a-5a. These were converted by dilute aqueous sodium hydroxide containing dimethylsulfoxide (DMSO) at concentrations between 0 and 60 vol-% into the methylenebis(allopurinols) 3b-5b by nucleophilic SNAr reactions at C(4). The effect of DMSO on the reaction kinetics was investigated.Entities:
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Year: 2007 PMID： 17851411 PMCID： PMC6149505 DOI： 10.3390/12030563
Source DB: PubMed Journal: Molecules ISSN： 1420-3049 Impact factor: 4.411