Literature DB >> 17851108

LSD1 and the chemistry of histone demethylation.

Jeffrey C Culhane1, Philip A Cole.   

Abstract

The recent discovery that histone demethylation can be catalyzed by the flavin-dependent amine oxidase LSD1 has ushered in a new chapter in the chromatin-remodeling community. Herein, we discuss the rapid progress of the histone demethylase field including the recent identification of the non-heme iron-dependent histone demethylases (JmjC family), the basis for LSD1 substrate site specificity and the newly emerging potential for inhibition of these enzymes in structural and functional analysis.

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Year:  2007        PMID： 17851108      PMCID： PMC2112775          DOI： 10.1016/j.cbpa.2007.07.014

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  48 in total

Review 1.  Translating the histone code.

Authors:  T Jenuwein; C D Allis
Journal:  Science       Date:  2001-08-10       Impact factor: 47.728

Review 2.  Re-SET-ting heterochromatin by histone methyltransferases.

Authors:  T Jenuwein
Journal:  Trends Cell Biol       Date:  2001-06       Impact factor: 20.808

3.  Enzymatic demethylation of calf thymus histones.

Authors:  W K Paik; S Kim
Journal:  Biochem Biophys Res Commun       Date:  1973-04-02       Impact factor: 3.575

Review 4.  Turns in peptides and proteins.

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Journal:  Adv Protein Chem       Date:  1985

Review 5.  Suicide substrates, mechanism-based enzyme inactivators: recent developments.

Authors:  C T Walsh
Journal:  Annu Rev Biochem       Date:  1984       Impact factor: 23.643

6.  Regulation of chromatin structure by site-specific histone H3 methyltransferases.

Authors:  S Rea; F Eisenhaber; D O'Carroll; B D Strahl; Z W Sun; M Schmid; S Opravil; K Mechtler; C P Ponting; C D Allis; T Jenuwein
Journal:  Nature       Date:  2000-08-10       Impact factor: 49.962

7.  Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase.

Authors:  Nicolas Lacoste; Rhea T Utley; Joanna M Hunter; Guy G Poirier; Jacques Côte
Journal:  J Biol Chem       Date:  2002-07-03       Impact factor: 5.157

8.  Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine.

Authors:  Maojun Yang; Jeffrey C Culhane; Lawrence M Szewczuk; Pegah Jalili; Haydn L Ball; Mischa Machius; Philip A Cole; Hongtao Yu
Journal:  Biochemistry       Date:  2007-06-15       Impact factor: 3.162

9.  Dot1p modulates silencing in yeast by methylation of the nucleosome core.

Authors:  Fred van Leeuwen; Philip R Gafken; Daniel E Gottschling
Journal:  Cell       Date:  2002-06-14       Impact factor: 41.582

10.  Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.

Authors:  Huck Hui Ng; Qin Feng; Hengbin Wang; Hediye Erdjument-Bromage; Paul Tempst; Yi Zhang; Kevin Struhl
Journal:  Genes Dev       Date:  2002-06-15       Impact factor: 11.361
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  61 in total

1.  Histone demethylase LSD1 is a folate-binding protein.

Authors:  Zigmund Luka; Frank Moss; Lioudmila V Loukachevitch; Darryl J Bornhop; Conrad Wagner
Journal:  Biochemistry       Date:  2011-05-05       Impact factor: 3.162

Review 2.  Metabolism strikes back: metabolic flux regulates cell signaling.

Authors:  Christian M Metallo; Matthew G Vander Heiden
Journal:  Genes Dev       Date:  2010-12-15       Impact factor: 11.361

3.  S-phase sensing of DNA-protein crosslinks triggers TopBP1-independent ATR activation and p53-mediated cell death by formaldehyde.

Authors:  Victor Chun-Lam Wong; Haley L Cash; Jessica L Morse; Shan Lu; Anatoly Zhitkovich
Journal:  Cell Cycle       Date:  2012-07-01       Impact factor: 4.534

4.  Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures.

Authors:  Shannon L Nowotarski; Boobalan Pachaiyappan; Steven L Holshouser; Craig J Kutz; Youxuan Li; Yi Huang; Shiv K Sharma; Robert A Casero; Patrick M Woster
Journal:  Bioorg Med Chem       Date:  2015-02-07       Impact factor: 3.641

5.  Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs.

Authors:  Claudia Binda; Milagros Aldeco; Werner J Geldenhuys; Marcello Tortorici; Andrea Mattevi; Dale E Edmondson
Journal:  ACS Med Chem Lett       Date:  2011-10-15       Impact factor: 4.345

6.  Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression.

Authors:  Sara A Miller; Sarah E Mohn; Amy S Weinmann
Journal:  Mol Cell       Date:  2010-11-24       Impact factor: 17.970

Review 7.  Epigenetic mechanisms facilitating oligodendrocyte development, maturation, and aging.

Authors:  Sjef Copray; Jimmy Long Huynh; Falak Sher; Patrizia Casaccia-Bonnefil; Erik Boddeke
Journal:  Glia       Date:  2009-11-15       Impact factor: 7.452

8.  Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity.

Authors:  Martin L Schmitt; Alexander-Thomas Hauser; Luca Carlino; Martin Pippel; Johannes Schulz-Fincke; Eric Metzger; Dominica Willmann; Teresa Yiu; Michelle Barton; Roland Schüle; Wolfgang Sippl; Manfred Jung
Journal:  J Med Chem       Date:  2013-09-05       Impact factor: 7.446

Review 9.  Chemical probes for histone-modifying enzymes.

Authors:  Philip A Cole
Journal:  Nat Chem Biol       Date:  2008-10       Impact factor: 15.040

10.  Identification of two SET domain proteins required for methylation of lysine residues in yeast ribosomal protein Rpl42ab.

Authors:  Kristofor J Webb; Arthur Laganowsky; Julian P Whitelegge; Steven G Clarke
Journal:  J Biol Chem       Date:  2008-10-28       Impact factor: 5.157
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