| Literature DB >> 17851074 |
Scott G Stewart1, Daniel Spagnolo, Marta E Polomska, Melvin Sin, Mahdad Karimi, Lawrence J Abraham.
Abstract
A library of new thalidomide analogues containing an olefin functionality were synthesised using a Heck cross coupling reaction from their aryl halogenated precursor. All analogues were tested for their ability to inhibit the synthesis of the proinflammatory cytokine Tumour Necrosis Factor (TNF). Compounds 22, 29, 33 and 37 were the most effective in this assay inhibiting TNF expression 50%, 69%, 52% and 50%, respectively.Entities:
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Year: 2007 PMID： 17851074 DOI： 10.1016/j.bmcl.2007.08.042
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823