| Literature DB >> 17850927 |
Annica Sjölander1, Lennart Minthon, Nenad Bogdanovic, Anders Wallin, Henrik Zetterberg, Kaj Blennow.
Abstract
Recently, a single nucleotide polymorphism (SNP, rs1800206) in the peroxisome proliferator-activated receptor alpha (PPAR-alpha) gene has been proposed to be associated with Alzheimer's disease (AD). To verify this finding, we analyzed the PPAR-alpha SNP in 461 patients with AD and 1395 controls. In subgroups, PPAR-alpha gene data could be investigated in relation to biochemical and neuropathological markers for AD. We found no significant differences in genotype or allele distributions between AD patients and controls. None of the PPAR-alpha gene variants influenced markers for AD.Entities:
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Year: 2007 PMID： 17850927 DOI： 10.1016/j.neurobiolaging.2007.07.018
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673