Literature DB >> 17850093

A one-step fusion of 1,3-thiazine and pyrimidine cycles.

Sergey V Ryabukhin1, Andrey S Plaskon, Eugeniy N Ostapchuk, Dmitriy M Volochnyuk, Oleg V Shishkin, Alexander N Shivanyuk, Andrey A Tolmachev.   

Abstract

The chlorotrimethylsilane-promoted Biginelli type reactions of aldehydes, thiourea, and cyanoketones led to a diverse set of tetrahydropyrimidine-2(1H)-thiones. Under similar conditions, thioureas, benzaldehyde, and cyanoacetamide reacted to give first representatives of hexahydro-5H-pyrimido[5,4-e][1,3]thiazin-5-ones in high preparative yield.

Entities:  

Year:  2007        PMID: 17850093     DOI: 10.1021/ol701782v

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  4 in total

1.  Aminoheterocycles as synthons for combinatorial Biginelli reactions.

Authors:  Sergey V Ryabukhin; Andrey S Plaskon; Sergey Yu Boron; Dmitriy M Volochnyuk; Andrey A Tolmachev
Journal:  Mol Divers       Date:  2010-05-07       Impact factor: 2.943

2.  Combinatorial synthesis of chemical building blocks 1. Azomethines.

Authors:  Sergey V Ryabukhin; Dmitriy M Panov; Andrey S Plaskon; Alexander Chuprina; Sergey E Pipko; Andrey A Tolmachev; Alexander N Shivanyuk
Journal:  Mol Divers       Date:  2012-10-30       Impact factor: 2.943

3.  Retracted Article: Boric acid in magnetized water: clean and powerful media for synthesis of 3,4-dihydropyrimidin-2(1H)-ones.

Authors:  Vahid Khakyzadeh; Ahmad Reza Moosavi-Zare; Sahra Sheikhaleslami; Amir Ehsani; Salbin Sediqi; Mohammad Rezaei-Gohar; Zahra Jalilian
Journal:  RSC Adv       Date:  2021-06-28       Impact factor: 4.036

4.  Effect of N-1 arylation of monastrol on kinesin Eg5 inhibition in glioma cell lines.

Authors:  Itamar Luís Gonçalves; Liliana Rockenbach; Gustavo Machado das Neves; Gabriela Göethel; Fabiana Nascimento; Luciano Porto Kagami; Fabrício Figueiró; Gabriel Oliveira de Azambuja; Amanda de Fraga Dias; Andressa Amaro; Lauro Mera de Souza; Ivan da Rocha Pitta; Daiana Silva Avila; Daniel Fábio Kawano; Solange Cristina Garcia; Ana Maria Oliveira Battastini; Vera Lucia Eifler-Lima
Journal:  Medchemcomm       Date:  2018-04-17       Impact factor: 3.597

  4 in total

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