Literature DB >> 17848077

Conjugation of polyamidoamine dendrimers on biodegradable microparticles for nonviral gene delivery.

Xue-Qing Zhang1, Janjira Intra, Aliasger K Salem.   

Abstract

We report on the preparation and characterization of poly(D, L-lactide-co-glycolide) (PLGA) microparticles with surface-conjugated polyamidoamine (PAMAM) dendrimers of varying generations. The buffering capacity and zeta-potential of the PLGA PAMAM microparticles increased with increasing generation level of the PAMAM dendrimer conjugated. Conjugation of the PAMAM dendrimer to the surface of the PLGA microparticle removed generation-dependent cytotoxicity in HEK293 and COS7 cell lines. PLGA PAMAM pDNA microparticles displayed similar cytotoxicity profiles to unmodified PLGA pDNA microparticles in COS7 cells. A generation three PAMAM dendrimer conjugated to PLGA microparticles significantly increased transfection efficiencies in comparison to unmodified PLGA microparticles.

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Year:  2007        PMID： 17848077     DOI： 10.1021/bc070116l

Source DB:  PubMed          Journal:  Bioconjug Chem        ISSN： 1043-1802            Impact factor:   4.774


  20 in total

1.  Polymeric nucleic acid vehicles exploit active interorganelle trafficking mechanisms.

Authors:  Katye M Fichter; Nilesh P Ingle; Patrick M McLendon; Theresa M Reineke
Journal:  ACS Nano       Date:  2012-12-31       Impact factor: 15.881

2.  PEGylated polyamidoamine dendrimers with bis-aryl hydrazone linkages for enhanced gene delivery.

Authors:  Quan Yuan; W Andrew Yeudall; Hu Yang
Journal:  Biomacromolecules       Date:  2010-08-09       Impact factor: 6.988

Review 3.  Nanoparticle-mediated brain-specific drug delivery, imaging, and diagnosis.

Authors:  Hu Yang
Journal:  Pharm Res       Date:  2010-07-01       Impact factor: 4.200

Review 4.  Innovative strategies for co-delivering antigens and CpG oligonucleotides.

Authors:  Yogita Krishnamachari; Aliasger K Salem
Journal:  Adv Drug Deliv Rev       Date:  2009-01-19       Impact factor: 15.470

5.  Characterization of the transgene expression generated by branched and linear polyethylenimine-plasmid DNA nanoparticles in vitro and after intraperitoneal injection in vivo.

Authors:  Janjira Intra; Aliasger K Salem
Journal:  J Control Release       Date:  2008-04-24       Impact factor: 9.776

6.  Fabrication, characterization and in vitro evaluation of poly(D,L-lactide-co-glycolide) microparticles loaded with polyamidoamine-plasmid DNA dendriplexes for applications in nonviral gene delivery.

Authors:  Janjira Intra; Aliasger K Salem
Journal:  J Pharm Sci       Date:  2010-01       Impact factor: 3.534

7.  Polymeric nanocarriers for transport modulation across the pulmonary epithelium: dendrimers, polymeric nanoparticles, and their nanoblends.

Authors:  Balaji Bharatwaj; Radovan Dimovski; Denise S Conti; Sandro R P da Rocha
Journal:  AAPS J       Date:  2014-04-02       Impact factor: 4.009

Review 8.  Nanoparticle-Based Delivery of CRISPR/Cas9 Genome-Editing Therapeutics.

Authors:  Brittany E Givens; Youssef W Naguib; Sean M Geary; Eric J Devor; Aliasger K Salem
Journal:  AAPS J       Date:  2018-10-10       Impact factor: 4.009

9.  Zwitterionic chitosan-polyamidoamine dendrimer complex nanoparticles as a pH-sensitive drug carrier.

Authors:  Karen C Liu; Yoon Yeo
Journal:  Mol Pharm       Date:  2013-04-03       Impact factor: 4.939

Review 10.  Biomimetic Mineralization of Biomaterials Using Simulated Body Fluids for Bone Tissue Engineering and Regenerative Medicine<sup/>.

Authors:  Kyungsup Shin; Timothy Acri; Sean Geary; Aliasger K Salem
Journal:  Tissue Eng Part A       Date:  2017-05-22       Impact factor: 4.080
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